Results 91 to 100 of about 15,680 (203)

Caffeine affects the biological responses of human hematopoietic cells of myeloid lineage via downregulation of the mTOR pathway and xanthine oxidase activity [PDF]

, 2015
Correction of human myeloid cell function is crucial for the prevention of inflammatory and allergic reactions as well as leukaemia progression. Caffeine, a naturally occurring food component, is known to display anti-inflammatory effects which have ...
Abooali, Maryam, Berger, Steffen M., Casely-Hayford, Maxwell A., Fasler-Kan, Elizaveta, Gibbs, Bernhard F., Gonçalves Silva, Isabel, Prokhorov, Alexandr, Sumbayev, Vadim V., Yasinska, Inna M.   +8 more
core   +3 more sources

Chemical Constituents of Taxodium mucronatum (Cupressaceae) and Some of Its Endophytic Fungi, and Their In Silico and In Vitro Evaluations as SARS‐CoV‐2 Inhibitors and as Cytotoxic Agents

Chemistry &Biodiversity, Volume 23, Issue 3, March 2026.
Abietanes, pimaranes and cycloartanes were characterized from different plant tissues of Taxodium mucronatum. Curvularins, mycophenolic acids and ergosterol were isolated from some fungal endophytes. The isolated compounds were in silico and in vitro evaluated as antiviral and cytotoxic agents.
Nadia Mendoza, Olivia Pérez‐Valera, Antonio Nieto‐Camacho, María Teresa Ramírez‐Apan, Marcela Guadalupe Téllez‐Martínez, Eleazar M. Escamilla‐Silva, Guillermo Delgado   +6 more
wiley   +1 more source

IMPDH2 dephosphorylation under FGFR signaling promotes S-phase progression and tumor growth

Cell Reports
Summary: Inosine monophosphate dehydrogenase 2 (IMPDH2) is highly expressed in human cancers; however, its physiological relevance under growth signaling remains to be investigated. Here, we show that IMPDH2 serine 122 is phosphorylated by CDK1, and this
Bei Zhou, Qin Zhao, Guofang Hou, Jing He, Nannan Sha, Ke Zheng, Hongyu Peng, Wang Wang, Yue Zhou, Tao Chen, Yuhui Jiang   +10 more
doaj   +1 more source

Lethal Mutagenesis of Picornaviruses with N-6-Modified Purine Nucleoside Analogues [PDF]

, 2008
RNA viruses exhibit extraordinarily high mutation rates during genome replication. Nonnatural ribonucleosides that can increase the mutation rate of RNA viruses by acting as ambiguous substrates during replication have been explored as antiviral agents ...
Barr, Eric W., Bollinger, J. Martin, Jr., Brown, Daniel M., Cameron, Craig E., Edathil, Jocelyn P., Galarraga, Jessica E., Graci, Jason D., Harki, Daniel A., Loakes, David, Peterson, Blake R., Smidansky, Eric D., Too, Kathleen   +11 more
core   +4 more sources

Tocotrienols: A Review From Source to Therapeutic Applications

Food Frontiers, Volume 7, Issue 2, March 2026.
Tocotrienols demonstrate superior antioxidant, neuroprotective, and anti‐inflammatory properties compared to conventional vitamin E forms, with promising therapeutic applications across multiple disorders when delivered through optimized systems that enhance their inherently limited bioavailability.
Natalia‐Carolina Londoño, Nidia Casas‐Forero, Andres‐Felipe Garzón‐Méndez, Dalí‐Aleixandra Rojas‐Díaz, Mary‐Luz Olivares‐Tenorio, Hernan‐Mauricio Romero, Jesús‐Alberto García‐Núñez   +6 more
wiley   +1 more source

Therapeutic effect of nucleoside analogs on experimental autoimmune encephalomyelitis in dark agouti rats [PDF]

, 2006
Experimental autoimmune encephalomyelitis (EAE) is a commonly used animal model of the human neurological disorder multiple sclerosis. The purpose of the present study was to investigate the effect of combined treatment with two nucleoside analogs ...
Bjelobaba Ivana, Gađanski Ivana, Lavrnja Irena, Mostarica-Stojković Marija, Peković Sanja, Rakić Lj., Stojiljković Mirjana, Stojkov Danijela, Stošić-Grujičić Stanislava, Šubašić Sanja   +9 more
core   +1 more source

The Role of One‐Carbon Metabolism in Cancer and Its Therapeutic Significance

MedComm – Oncology, Volume 5, Issue 1, March 2026.
One‐Carbon metabolism in T‐cell activation and tumor competition. T‐cell activation shifts metabolic pathways, promoting anabolic metabolism and bioenergetic capacity. One‐carbon metabolism plays a crucial role in histone and DNA methylation in activated T cells.
Yuting Jiang, Guoliang Zhou, Qian Zhang, Shengtao Zhou   +3 more
wiley   +1 more source

Purine synthesis promotes maintenance of brain tumor initiating cells in glioma [PDF]

, 2018
Brain tumor initiating cells (BTICs), also known as cancer stem cells, hijack high-affinity glucose uptake active normally in neurons to maintain energy demands.
Bao, Shideng, Fang, Xiaoguang, Flavahan, William A, Huang, Zhi, Hubert, Christopher G, Hwang, Tae Hyun, Kim, Leo J Y, Liu, Xiaojing, Locasale, Jason W, Mack, Stephen C, Miller, Tyler E, Prager, Briana C, Regev, Aviv, Rich, Jeremy N, Shi, Yu, Singer, Meromit, Suvà, Mario L, Wang, Xiuxing, Wu, Qiulian, Xie, Qi, Yang, Kailin, Zhou, Wenchao   +21 more
core   +1 more source

Crystallization and preliminary X-ray analysis of mycophenolic acid-resistant and mycophenolic acid-sensitive forms of IMP dehydrogenase from the human fungal pathogen Cryptococcus [PDF]

, 2010
Fungal human pathogens such as Cryptococcus neoformans are becoming an increasingly prevalent cause of human morbidity and mortality owing to the increasing numbers of susceptible individuals.
Allison, Anna Stamp, Bostjan Kobe, Carl A. Morrow, Chen, Collaborative Computational Project, Number 4, Elion, Escobar-Henriques, Eugene Valkov, Guillen Schlippe, Hedstrom, Hyle, Jackson, James A. Fraser, Kabsch, Kaur, Kohler, McMillan, Park, Prosise, Riera, Shaw, Sintchak, Umejiego, Zhang   +24 more
core   +1 more source

Diversity of mechanisms to control bacterial GTP homeostasis by the mutually exclusive binding of adenine and guanine nucleotides to IMP dehydrogenase. [PDF]

Protein Sci, 2022
Fernández-Justel D, Marcos-Alcalde Í, Abascal F, Vidaña N, Gómez-Puertas P, Jiménez A, Revuelta JL, Buey RM.   +7 more
europepmc   +1 more source