Results 151 to 160 of about 15,680 (203)
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IMP Dehydrogenase: Structural Aspects of Inhibitor Binding
Current Medicinal Chemistry, 1999Inosine monophosphate dehydrogenase (IMPDH, E.C. 1.1.1.205) is recognized as an important target for both antileukemic and immunosuppressive therapy. IMPDH catalyzes the NAD-dependent oxidation of inosine 5' monophosphate (IMP) to xanthosine 5' monophosphate. Several classes of IMPDH inhibitors are now in use or under development.
B M, Goldstein, T D, Colby
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Identification of the IMP binding site in the IMP dehydrogenase from Tritrichomonas foetus
Biochemistry, 1995The IMP dehydrogenase from Tritrichomonas foetus has been identified as a potential target for antitritrichomonial chemotherapy. The gene encoding this enzyme was expressed in transformed Escherichia coli, and the recombinant protein was purified to homogeneity with an average yield of 3 mg of protein per liter of bacterial culture.
J A, Huete-Pérez +3 more
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A straightforward radiometric technique for measuring IMP dehydrogenase
Analytical Biochemistry, 1983[2-3H]Inosinic acid ([2-3H]IMP) has been biosynthesized in good yield from [2-3H]hypoxanthine and PRPP via the action of a partially purified preparation of hypoxanthine/guanine phosphoribosyl transferase from mouse brain. The product was purified in one step by ascending paper chromatography, and used to assess the activity of IMP dehydrogenase.
D A, Cooney, Y, Wilson, E, McGee
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IMP dehydrogenase: structural schizophrenia and an unusual base
Current Opinion in Chemical Biology, 2006Textbooks describe enzymes as relatively rigid templates for the transition state of a chemical reaction, and indeed an enzyme such as chymotrypsin, which catalyzes a relatively simple hydrolysis reaction, is reasonably well described by this model. Inosine monophosphate dehydrogenase (IMPDH) undergoes a remarkable array of conformational transitions ...
Lizbeth, Hedstrom, Lu, Gan
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IMP Dehydrogenase-Linked Retinitis Pigmentosa
Nucleosides, Nucleotides and Nucleic Acids, 2008Many retinal diseases are caused by mutations in photoreceptor-specific proteins. However, retinal disease can also result from mutations in widely expressed proteins. One such protein is inosine monophosphate dehydrogenase type 1 (IMPDH1), which catalyzes a key step in guanine nucleotide biosynthesis and also binds single-stranded nucleic acids.
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Purification of IMP dehydrogenase from rat hepatoma 3924A
Life Sciences, 1987IMP dehydrogenase (EC 1.1.1.205), the rate-limiting enzyme of de novo GTP biosynthesis and a promising target for cancer chemotherapy, was purified 4860-fold to homogeneity from rat hepatoma 3924A by a method including affinity chromatography in which IMP is bound to epoxy-activated Sepharose 6B.
T, Ikegami, Y, Natsumeda, G, Weber
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Metabolism of the Novel IMP Dehydrogenase Inhibitor Benzamide Riboside
Medicinal Chemistry Reviews - Online, 2002Benzamide riboside (BR) is a novel anticancer agent exhibiting pronounced activity against several human tumor cell lines via the inhibition of inosine 5'-monophosphate dehydrogenase (IMPDH) that catalyzes the formation of xanthine 5'-monophosphate from inosine 5'-monophosphate and nicotinamide adenine dinucleotide, thereby restricting the biosynthesis
Jäger, Walter +2 more
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A Potent “Fat Base” Nucleotide Inhibitor of IMP Dehydrogenase
Biochemistry, 1998Inosine monophosphate dehydrogenase (IMPDH) is a target for anticancer, antiviral, immunosuppressive, and antimicrobial chemotherapy. Thus, IMPDH inhibitors have great potential as chemotherapeutic agents. Here we show that imidazo[4,5-e][1, 4]diazapine nucleotide (I) is a potent inhibitor of both human type II and Escherichia coli IMPDH.
W, Wang, L, Hedstrom
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Differential Signatures of Bacterial and Mammalian IMP Dehydrogenase Enzymest
Current Medicinal Chemistry, 1999IMP dehydrogenase (IMPDH) is an essential enzyme of de novo guanine nucleotide synthesis. IMPDH inhibitors have clinical utility as antiviral, anticancer or immunosuppressive agents. The essential nature of this enzyme suggests its therapeutic applications may be extended to the development of antimicrobial agents.
R, Zhang +6 more
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IMP dehydrogenase, an enzyme linked with proliferation and malignancy
Nature, 1975PREVIOUS studies conducted in this laboratory demonstrated that in a spectrum of liver tumours with different growth rates there is an imbalance in the activities of key enzymes and competing pathways of carbohydrate, pyrimidine, DNA and ornithine metabolism1–4.
R C, Jackson, G, Weber, H P, Morris
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