Comprehensive transcriptomic and metabolomic analysis provides insight into transportation stress effects on fish muscle quality [PDF]
npj Science of FoodTransportation, a critical link in the aquaculture industry chain, triggers significant economic losses through stress-induced muscle quality deterioration in fish.
Yujie Meng +10 more
doaj +2 more sources
IMP dehydrogenase: the dynamics of drug selectivity [PDF]
Nucleic Acids Symposium Series, 2003 Inosine monophosphate dehydrogenase (IMPDH) is an important target for immunosuppressive, antiviral and anticancer therapy. This enzyme catalyzes the key reaction in guanine nucleotide biosynthesis: the conversion of IMP into XMP with the concomitant reduction of NAD.
Lizbeth, Hedstrom +4 more
openaire +4 more sources
Scientific Reports, 2022 Inosine triphosphate pyrophosphatases (ITPases) are ubiquitous house-cleaning enzymes that specifically recognize deaminated purine nucleotides and catalyze their hydrolytic cleavage.
Antonio E. Vidal +5 more
doaj +1 more source
Dietary essential oils modulate post-mortem oxidative damage in trout fillets exposed to slaughter stress during frozen storage. [PDF]
J Sci Food AgricAbstract BACKGROUND Slaughter is a critical phase in aquaculture that can severely compromise both animal welfare and product quality. Stress responses triggered during this stage may accelerate post‐mortem biochemical degradation and promote oxidative damage in fish fillets. Essential oils, known for their antioxidant and anti‐inflammatory properties,
Méndez L +5 more
europepmc +2 more sources
IMP Dehydrogenase Inhibitors as Immunomodulators [PDF]
Annals of the New York Academy of Sciences, 1993 IMP dehydrogenase is a key enzyme in the de novo pathway of purine biosynthesis and is responsible for catalyzing the first step in the formation of guanine ribonucleotides from inosine monophosphate. Mizoribine, an immunosuppressive agent in wide-spread clinical use in Japan, has been demonstrated to inhibit this enzyme.
Mitchell, Beverly S. +3 more
openaire +3 more sources
Multiscale metabolic modeling of C4 plants: connecting nonlinear genome-scale models to leaf-scale metabolism in developing maize leaves [PDF]
, 2015 C4 plants, such as maize, concentrate carbon dioxide in a specialized compartment surrounding the veins of their leaves to improve the efficiency of carbon dioxide assimilation.
Bogart, Eli, Myers, Christopher R.
core +7 more sources
IMP dehydrogenase rod/ring structures in acral melanomas [PDF]
Pigment Cell & Melanoma Research, 2020 AbstractAcral lentiginous melanoma (ALM) is a rare subtype of melanoma with aggressive behavior. IMPDH enzyme, involved in de novo GTP biosynthesis, has been reported to assemble into large filamentary structures called rods/rings (RR) or cytoophidium (cellular snakes).
Gerson D. Keppeke +8 more
openaire +3 more sources
Toxins, 2011 We have identified a novel nucleotide, 4-pyridone 3/5-carboxamide ribonucleoside triphosphate (4PyTP), which accumulates in human erythrocytes during renal failure.
Elizabeth A. Carrey +5 more
doaj +1 more source
Mycobacterium tuberculosis IMPDH in Complexes with Substrates, Products and Antitubercular Compounds. [PDF]
PLoS ONE, 2015 Tuberculosis (TB) remains a worldwide problem and the need for new drugs is increasingly more urgent with the emergence of multidrug- and extensively-drug resistant TB.
Magdalena Makowska-Grzyska +13 more
doaj +1 more source
Metabolomic profiling of macrophages determines the discrete metabolomic signature and metabolomic interactome triggered by polarising immune stimuli [PDF]
, 2018 Priming and activating immune stimuli have profound effects on macrophages, however, studies generally evaluate stimuli in isolation rather than in combination.
Achcar, Fiona +6 more
core +3 more sources