Metabolic engineering of the purine biosynthetic pathway in Corynebacterium glutamicum results in increased intracellular pool sizes of IMP and hypoxanthine [PDF]
, 2012 Background: Purine nucleotides exhibit various functions in cellular metabolism. Besides serving as building blocks for nucleic acid synthesis, they participate in signaling pathways and energy metabolism.
Barduhn, Tobias +5 more
core +1 more source
A quantitative screen for metabolic enzyme structures reveals patterns of assembly across the yeast metabolic network. [PDF]
, 2019 Despite the proliferation of proteins that can form filaments or phase-separated condensates, it remains unclear how this behavior is distributed over biological networks. We have found that 60 of the 440 yeast metabolic enzymes robustly form structures,
Begovich, Kyle +5 more
core +3 more sources
Performance of the Roche Total Mycophenolic Acid® assay on the Cobas Integra 400®, Cobas 6000® and comparison to LC-MS/MS in liver transplant patients [PDF]
, 2011 Background: Mycophenolic acid (MPA) is an immunosuppressant for which therapeutic drug monitoring (TDM) is performed for optimal prophylaxis and avoidance of toxicity in transplant patients.
Decavele, An-Sofie +3 more
core +1 more source
Drugs and Drug Candidates, 2023 Liver cancer is a high mortality cancer, and its increasing prevalence is a concern worldwide. Current treatment modalities for liver cancer include chemotherapy and immunotherapy.
Ruchi Jakhmola Mani +8 more
doaj +1 more source
One-carbon metabolism in cancer [PDF]
, 2017 Cells require one-carbon units for nucleotide synthesis, methylation and reductive metabolism, and these pathways support the high proliferative rate of cancer cells.
AJ MacFarlane +55 more
core +1 more source
Identification of novel Mt-Guab2 inhibitor series active against M. tuberculosis.
PLoS ONE, 2012 Tuberculosis (TB) remains a leading cause of mortality worldwide. With the emergence of multidrug resistant TB, extensively drug resistant TB and HIV-associated TB it is imperative that new drug targets be identified.
Veeraraghavan Usha +4 more
doaj +1 more source
Sensory and ATP derivative-based indicators for assessing the freshness of Atlantic salmon (Salmo salar) and cod (Gadus morhua) [PDF]
, 2019 peer-reviewedIrish Journal of Agricultural and Food Research | Volume 58: Issue 1 Sensory and ATP derivative-based indicators for assessing the freshness of Atlantic salmon (Salmo salar) and cod (Gadus morhua)
Bolton, Declan +4 more
core +1 more source
Two classes of bacterial IMPDHs according to their quaternary structures and catalytic properties.
PLoS ONE, 2015 Inosine-5'-monophosphate dehydrogenase (IMPDH) occupies a key position in purine nucleotide metabolism. In this study, we have performed the biochemical and physico-chemical characterization of eight bacterial IMPDHs, among which six were totally ...
Thomas Alexandre +2 more
doaj +1 more source
Acta Medica Iranica, 2023 Inosine 5-monophosphate dehydrogenase 1 (IMPDH1) is the rate-limiting enzyme in the de novo purine nucleotide biosynthesis. IMPDH1 catalyzes IMP-oxidation to XMP, which in continue is converted to guanine nucleotides. Like mammals, the mouse IMPDH1 (mH1)
Behnaz Andashti +2 more
doaj +1 more source
Comparative genomic analysis of novel Acinetobacter symbionts : A combined systems biology and genomics approach [PDF]
, 2016 Acknowledgements This work was supported by University of Delhi, Department of Science and Technology- Promotion of University Research and Scientific Excellence (DST-PURSE). V.G., S.H. and U.S.
Forbes, Ken +8 more
core +4 more sources