Results 31 to 40 of about 15,680 (203)

Network reconstruction of platelet metabolism identifies metabolic signature for aspirin resistance. [PDF]

, 2014
Recently there has not been a systematic, objective assessment of the metabolic capabilities of the human platelet. A manually curated, functionally tested, and validated biochemical reaction network of platelet metabolism, iAT-PLT-636, was reconstructed
Bordbar, Aarash, Jamshidi, Neema, Palsson, Bernhard Ø, Rahmanian, Sorena, Thomas, Alex   +4 more
core   +2 more sources

Repurposing existing drugs: identification of irreversible IMPDH inhibitors by high-throughput screening

Journal of Enzyme Inhibition and Medicinal Chemistry, 2019
Inosine 5′-monophosphate dehydrogenase (IMPDH) is an essential enzyme for the production of guanine nucleotides. Disruption of IMPDH activity has been explored as a therapeutic strategy for numerous purposes, such as for anticancer, immunosuppression ...
Albertus Eka Yudistira Sarwono, Shinya Mitsuhashi, Mohammad Hazzaz Bin Kabir, Kengo Shigetomi, Tadashi Okada, Fumina Ohsaka, Satoko Otsuguro, Katsumi Maenaka, Makoto Igarashi, Kentaro Kato, Makoto Ubukata   +10 more
doaj   +1 more source

Feedlot performance and immune function analysis of implanted and non-implanted steers selected for alcohol dehydrogenase 1 C (ADH1C) genotype and fed a low vitamin A diet

Animal, 2019
Previous studies have shown that the interaction between limiting vitamin A (VA) and an alcohol dehydrogenase 1 C (ADH1C) variant in beef cattle results in increased intramuscular fat in the longissimus thoracis muscle in one genotype when fed low ...
K.M. Madder, J.J. McKinnon, G.W. Torres, K.G. Krone, J.L. Duncombe, C.D. Luby, F.C. Buchanan   +6 more
doaj   +1 more source

Imperatorin as a Promising Chemotherapeutic Agent against Human Larynx Cancer and Rhabdomyosarcoma Cells

Molecules, 2020
Naturally occurring coumarins are bioactive compounds widely used in Asian traditional medicine. They have been shown to inhibit proliferation, induce apoptosis, and/or enhance the cytotoxicity of currently used drugs against a variety of cancer cell ...
Aneta Grabarska, Krystyna Skalicka-Woźniak, Michał Kiełbus, Magdalena Dmoszyńska-Graniczka, Paulina Miziak, Justyna Szumiło, Ewa Nowosadzka, Krystyna Kowalczuk, Sherief Khalifa, Jolanta Smok-Kalwat, Janusz Klatka, Krzysztof Kupisz, Krzysztof Polberg, Adolfo Rivero-Müller, Andrzej Stepulak   +14 more
doaj   +1 more source

Mycophenolic acid (MPA) modulates host cellular autophagy progression in sub genomic dengue virus-2 replicon cells [PDF]

, 2019
Cellular autophagy (Macrophagy) is a self-degradative process, executed through the network of autophagy associated genes (ATGs) encoded proteins. Both in vitro and in vivo studies suggest that dengue virus (DENV) induces autophagy and supports the viral
Dungdung, Ranjeet, Manchala, Nageswar Reddy, Pilankatta, Rajendra, Trivedi, Pankaj, Unniyampurath, Unnikrishnan   +4 more
core   +1 more source

Increased Adenine Nucleotide Degradation in Skeletal Muscle Atrophy [PDF]

, 2019
Adenine nucleotides (AdNs: ATP, ADP, AMP) are essential biological compounds that facilitate many necessary cellular processes by providing chemical energy, mediating intracellular signaling, and regulating protein metabolism and solubilization.
Brault, Jeffrey J., Hafen, Paul S., Miller, Spencer G.   +2 more
core   +1 more source

Adaptive evolution of drug targets in producer and non-producer organisms [PDF]

, 2012
Mycophenolic acid (MPA) is an immunosuppressive drug produced by several fungi in Penicillium subgenus Penicillium. This toxic metabolite is an inhibitor of IMP dehydrogenase (IMPDH). The MPA biosynthetic cluster of P.
Balzarini, Bentley, Bjarne G. Hansen, Chooi, Christian S. Kaas, Collart, Farazi, Frisvad, Frisvad, Gao, Geu-Flores, Hansen, Hansen, Hans J. Genee, Hartman, Hedstrom, Hoff, Jakob B. Nielsen, Jenks, Jens C. Frisvad, Khersonsky, Kohler, Kohler, Lightfoot, Link, Lizbeth Hedstrom, MacPherson, Nimmesgern, Norholm, O'Brien, Regueira, Saitou, Sintchak, Tracewell, Uffe H. Mortensen, van den Berg, Wang, Wilson, Wilson, Wu, Xin E. Sun   +40 more
core   +1 more source

A new class of IMP dehydrogenase with a role in self-resistance of mycophenolic acid producing fungi

BMC Microbiology, 2011
Background Many secondary metabolites produced by filamentous fungi have potent biological activities, to which the producer organism must be resistant.
Mortensen Uffe H, Regueira Torsten B, Nielsen Jakob B, Kaas Christian S, Genee Hans J, Hansen Bjarne G, Frisvad Jens C, Patil Kiran R   +7 more
doaj   +1 more source

Host Cell Amplification of Nutritional Stress Contributes To Persistence in Chlamydia trachomatis

mBio, 2022
Persistence, a viable but non-replicating growth state, has been implicated in diseases caused by Chlamydia trachomatis. Starvation of distinct nutrients produces a superficially similar persistent state, implying convergence on a common intracellular ...
Nick D. Pokorzynski, Monisha R. Alla, Rey A. Carabeo   +2 more
doaj   +1 more source

Translesion synthesis DNA polymerase η exhibits a specific RNA extension activity and a transcription-associated function [PDF]

, 2017
We thank Andres Aguilera for providing the pCYC-LacZ plasmid for the GLRO experiments, and Szilvia Minorits for technical assistance. This work was also supported by grants from the National Research, Development and Innovation Office: GINOP-2.3.2-15 ...
Balint, Eva, Frittmann, Orsolya, Gali, Vamsi K, Serbyn, Nataliia, Stutz, Francoise, Unk, Ildiko   +5 more
core   +3 more sources