Results 51 to 60 of about 15,680 (203)

IMP/GTP balance modulates cytoophidium assembly and IMPDH activity

Cell Division, 2018
Background Inosine monophosphate dehydrogenase (IMPDH), the rate-limiting enzyme in de novo GTP biosynthesis, plays an important role in cell metabolism and proliferation.
Gerson Dierley Keppeke, Chia Chun Chang, Min Peng, Li-Yu Chen, Wei-Cheng Lin, Li-Mei Pai, Luis Eduardo Coelho Andrade, Li-Ying Sung, Ji-Long Liu   +8 more
doaj   +1 more source

IMP Dehydrogenase from the Protozoan ParasiteToxoplasma gondii [PDF]

Antimicrobial Agents and Chemotherapy, 2005
ABSTRACTThe opportunistic apicomplexan parasiteToxoplasma gondiidamages fetuses in utero and threatens immunocompromised individuals. The toxicity associated with standard antitoxoplasmal therapies, which target the folate pathway, underscores the importance of examining alternative pharmacological strategies.
Sullivan, William J., Jr., Dixon, Stacy E., Li, Catherine, Striepen, Boris, Queener, Sherry F.   +4 more
openaire   +2 more sources

Crucial involvement of xanthine oxidase in the intracellular signalling networks associated with human myeloid cell function [PDF]

, 2014
Xanthine oxidase (XOD) is an enzyme which plays a central role in purine catabolism by converting hypoxanthine into xanthine and then further into uric acid.
Abooali, Maryam, Coughlan, Karen, Gibbs, Bernhard F., Lall, Gurprit S., Lall, Harjinder S., Sumbayev, Vadim V.   +5 more
core   +1 more source

The characteristics of collagen‐induced rheumatoid arthritis in macaques and the changes of heart

Animal Models and Experimental Medicine, EarlyView.
The disease progression in CIA macaques was categorized into three stages: IIR (days 14–34): The indicators related to rheumatoid arthritis and the levels of immunoglobulin were all elevated. There was a small amount of joint effusion, edema and mild synovial hyperplasia. No joint swelling was observed by naked eye.
Lei Zhang, Haifeng Jiang, Zhen Xu, Tingyu Dong, Xiaoyi Liu, Shangxue Yan, Jiajie Kuai, Yan Chang, Wei Wei   +8 more
wiley   +1 more source

Expression of IMP dehydrogenase in differentiating HL-60 cells [PDF]

Blood, 1990
Abstract Addition of mycophenolic acid to cultures of HL-60 cells results in a decreased cellular level of guanine nucleotides and the induction of cell differentiation. During the early stages of this induction, steady- state levels of cellular IMP dehydrogenase (IMPDH), messenger RNA (mRNA), and protein are increased, perhaps because ...
F R, Collart, E, Huberman
openaire   +3 more sources

GuaB Activity Is Required in Rhizobium tropici During the Early Stages of Nodulation of Determinate Nodules but Is Dispensable for the Sinorhizobium meliloti–Alfalfa Symbiotic Interaction [PDF]

, 2005
The guaB mutant strain Rhizobium tropici CIAT8999-10T is defective in symbiosis with common bean, forming nodules that lack rhizobial content. In order to investigate the timing of the guaB requirement during the nodule formation on the host common ...
Aguilar, Orlando Mario, Collavino, Mónica Mariana, Crespi, Martín, Grasso, Daniel Horacio, Riccillo, Pablo M.   +4 more
core   +4 more sources

Adverse immunostimulation in early phase clinical trials: Key findings and recommendations based on the investigator's clinical experience

British Journal of Clinical Pharmacology, EarlyView.
Problem setting The emergence of therapeutic proteins has coincided with an increase of acute adverse immunostimulation (AIS). AIS has occured in clinical trials despite compliance with regulatory guidelines on preclinical evaluation and its incidence is anticipated to increase even further.
Juliette A. van den Noort, Marella C. E. van Ruissen, Lisanne C. A. Smidt, Naomi B. Klarenbeek, Philip H. K. Kremer, Manon A. A. Jansen, Jacobus Burggraaf, Joop M. A. van Gerven, Matthijs Moerland   +8 more
wiley   +1 more source

Hypoxanthine-guanine phosphoribosyltransferase and inosine 5’-monophosphate dehydrogenase activities in three mammalian species: aquatic (Mirounga angustirostris), semiaquatic (Lontra longicaudis annectens) and terrestrial (Sus scrofa)

Frontiers in Physiology, 2015
Aquatic and semiaquatic mammals have the capacity of breath hold (apnea) diving. Northern elephant seals (Mirounga angustirostris) have the ability to perform deep and long duration dives; during a routine dive, adults can hold their breath for 25 min ...
Myrna eBarjau Perez-Milicua, Tania eZenteno-Savin, Daniel E. Crocker, Juan Pablo Gallo   +3 more
doaj   +1 more source

The effect of adenosine monophosphate deaminase overexpression on the accumulation of umami-related metabolites in tomatoes [PDF]

, 2016
Taste is perceived as one of a combination of five sensations, sweet, sour, bitter, salty, and umami. The umami taste is best known as a savoury sensation and plays a central role in food flavour, palatability, and eating satisfaction.
A Inaba, A Sorrequieta, AI Fernandez, Alison Ferguson, Bee Lynn Chew, C Yoneda, CP Scott-Taggart, G Ferraro, Graham B. Seymour, Gregory A. Tucker, H Kisaka, H Kisaka, H Kisaka, H-J Sun, Ian D. Fisk, J Sambrook, J Xu, JE Dancer, K Kurihara, K Ninomiya, L Stryer, M Bemer, M Petro-Turza, N Bouché, N Nakajima, R Zrenner, RL Sabina, Rupert Fray, S Yamaguchi, S Yamaguchi, T Akihiro, The Tomato Genome Consortium, Wei Xia, Zsuzsanna Bodi   +33 more
core   +2 more sources

Gut microbiome‐derived metabolites show promise in cancer research and therapy

Interdisciplinary Medicine, EarlyView.
The metabolites produced by the gut microbiome, which are subject to regulation by multiple factors, play a pivotal role in the progression of various types of cancer. These metabolites not only function as potential biomarkers for the early detection and monitoring of tumor development, but also actively participate in cancer therapeutic processes ...
Kangjie Yang, Yifan Wang, Daolin Tang, Peilong Li, Lutao Du   +4 more
wiley   +1 more source