Results 71 to 80 of about 15,680 (203)

AllergoOncology in Review: Harnessing Allergy in the Field of Oncology to Improve Patient Outcomes

Clinical &Experimental Allergy, EarlyView.
ABSTRACT The AllergoOncology field brings together the study of allergic and cancer immune responses, having evolved from early epidemiological studies that reported inverse associations between allergies, IgE and cancer risk. Insights from studying allergic inflammation are revealing previously unappreciated immune mechanisms that confer protective ...
Jakub Zydron, Anishaa Balaji, Jitesh Chauhan, Jack Alder, Xinyi Chen, Anna M. F. Wiegman, Aurelie Poli, Joanna Jacków‐Malinowska, Jack Cheeseman, Daniel I. R. Spencer, James McDonnell, James Spicer, Alexandra J. McCraw, Sophia N. Karagiannis   +13 more
wiley   +1 more source

IMP Dehydrogenase Type 1 Associates with Polyribosomes Translating Rhodopsin mRNA [PDF]

Journal of Biological Chemistry, 2008
IMP dehydrogenase (IMPDH) catalyzes the pivotal step in guanine nucleotide biosynthesis. Here we show that both IMPDH type 1 (IMPDH1) and IMPDH type 2 are associated with polyribosomes, suggesting that these housekeeping proteins have an unanticipated role in translation regulation.
Sarah E, Mortimer, Dong, Xu, Dharia, McGrew, Nobuko, Hamaguchi, Hoong Chuin, Lim, Sara J, Bowne, Stephen P, Daiger, Lizbeth, Hedstrom   +7 more
openaire   +2 more sources

The glyceraldehyde-3-phosphate dehydrogenase GapDH of Corynebacterium diphtheriae is redox-controlled by protein S-mycothiolation under oxidative stress [PDF]

, 2017
Mycothiol (MSH) is the major low molecular weight (LMW) thiol in Actinomycetes and functions in post-translational thiol-modification by protein S-mycothiolation as emerging thiol-protection and redox-regulatory mechanism.
Adrian, Lorenz, Antelmann, Haike, Becher, Dörte, Bernhardt, Jörg, Hell, Rüdiger, Hillion, Melanie, Imber, Marcel, Loi, Vu Van, Maaß, Sandra, Messens, Joris, Pedre, Brandàn, Rosado, Leonardo Astolfi, Saleh, Malek, Weise, Christoph, Wirtz, Markus   +14 more
core   +1 more source

Moderate maternal nutrient restriction alters type II alveolar epithelial cell density in the non‐human primate fetal lung

Experimental Physiology, EarlyView.
Abstract Restriction of fetal substrate supply has an adverse effect on surfactant maturation in the lung and thus affects the transition from in utero placental oxygenation to pulmonary ventilation ex utero. However, the consequences of reduced fetal substrate supply are dependent on the timing of gestation, severity and duration.
Mitchell C. Lock, Hillary F. Huber, Cun Li, Sandra Orgeig, Peter W. Nathanielsz, Janna L. Morrison   +5 more
wiley   +1 more source

6‐Methylsulfinylhexyl isothiocyanate activates carbonic anhydrase‐dependent HCO3−/H+/Na+/Ca2+ transport via SLC4As–NHE–NCX–PMCA axis in odontoblasts

The Journal of Physiology, EarlyView.
Abstract figure legend 6‐Methylsulfinylhexyl isothiocyanate (6‐MSITC, hexaraphane), a wasabi sulfinyl compound, activates intracellular carbonic anhydrase (CA)‐mediated sequential HCO3−, Na+, H+ and Ca2+ transport through an activation axis involving HCO3−‐transporting solute carrier family 4 (SLC4As), the Na+–H+ exchanger (NHE), the Na+–Ca2+ exchanger
Yoshiaki Furusawa, Maki Kimura, Isao Okunishi, Takehito Ouchi, Ryuya Kurashima, Tomoe Katou‐Yamada, Hidetaka Kuroda, Makoto Sugita, Masahiro Furusawa, Yoshiyuki Shibukawa   +9 more
wiley   +1 more source

Bacterial IMPDH Gene Used for the Selection of Mammalian Cell Transfectants

BioTechniques, 2003
Stable cell transfection is used for the expression of exogenous genes or cDNAs in eukaryotic cells. Selection of these transfectants requires a dominant selectable marker. A variety of such markers has been identified and is currently in use.
Mekhine Baccam, Eliezer Huberman
doaj   +1 more source

Undercover: Gene control by metabolites and metabolic enzymes [PDF]

, 2016
To make the appropriate developmental decisions or maintain homeostasis, cells and organisms must coordinate the expression of their genome and metabolic state. However, the molecular mechanisms that relay environmental cues such as nutrient availability
Knaap, J.A. (Jan) van der, Verrijzer, C.P. (Peter)   +1 more
core   +2 more sources

Hypoxia and hypercapnia elicit overlapping but distinct skeletal muscle toxicities

The Journal of Physiology, EarlyView.
Abstract figure legend Hypoxia and hypercapnia cause overlapping skeletal muscle phenotypes, including atrophy, change in myofibre metabolic profile and myogenic response to injury. Both signals operate via distinct cellular pathways. Abstract Skeletal muscle dysfunction is strongly associated with elevated mortality in acute and chronic pulmonary ...
Joseph Balnis, Ariel Jaitovich
wiley   +1 more source

A journey into the regulatory secrets of the de novo purine nucleotide biosynthesis

Frontiers in Pharmacology
De novo purine nucleotide biosynthesis (DNPNB) consists of sequential reactions that are majorly conserved in living organisms. Several regulation events take place to maintain physiological concentrations of adenylate and guanylate nucleotides in cells ...
Nour Ayoub, Antoine Gedeon, Hélène Munier-Lehmann   +2 more
doaj   +1 more source

Neuraminidase activity provides a practical read-out for a high throughput influenza antiviral screening assay

Virology Journal, 2008
Background The emergence of influenza strains that are resistant to commonly used antivirals has highlighted the need to develop new compounds that target viral gene products or host mechanisms that are essential for effective virus replication. Existing
Wu Meng, Hassantoufighi Arash, Eichelberger Maryna C, Li Min   +3 more
doaj   +1 more source