Results 101 to 110 of about 13,192,083 (308)

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Probabilistic Analysis of the Economic Impact of Earthquake Prediction Systems [PDF]

open access: yes, 2014
This research initiates from the question of whether or not earthquake prediction systems are actually worth investing in, as the cost of operating such systems is quite large compared to the number of lives which may be saved and, furthermore, false ...
Yuan, Ruyue
core   +2 more sources

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

The impact of concentrated pig production in Flanders : a spatial analysis [PDF]

open access: yes, 2015
Historically concentrated livestock production and, consequently, manure production and management in Belgium have resulted in severe environmental impacts.
Buysse, Jeroen   +4 more
core  

Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells

open access: yesFEBS Letters, EarlyView.
Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López   +2 more
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Historic and future increase in the global land area affected by monthly heat extremes

open access: yesEnvironmental Research Letters, 2013
Climatic warming of about 0.5 ° C in the global mean since the 1970s has strongly increased the occurrence-probability of heat extremes on monthly to seasonal time scales. For the 21st century, climate models predict more substantial warming.
Dim Coumou, Alexander Robinson
doaj   +1 more source

Impact analysis of the CAP reform on main agricultural commodities [PDF]

open access: yes, 2007
End of project reportThis study has been carried out for the European Commission's Joint Research Centre to analyze agricultural policies at Member State, EU15 and EU25 levels as well as for Bulgaria and Romania. The modelling tool allows for projections
Donnellan, Trevor, Hanrahan, Kevin
core  

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

Current and future adaptation potential of heat-tolerant maize in Cameroon: a combined attribution and adaptation study

open access: yesEnvironmental Research Letters
Sub-Saharan Africa is projected to be exposed to substantial climate change hazards, especially in its agricultural sector, so adaptation will be necessary to safeguard crop yields.
Lennart Jansen   +2 more
doaj   +1 more source

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