Results 101 to 110 of about 499,828 (261)

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Analysis of Damping Characteristics of Magnetorheological Damper under Impact Load. [PDF]

Materials (Basel), 2022
Sun M, Li X, Zhou Z, Zhu Q, Liu B, Chen X, Wang J, Zhang G, Cai S.   +8 more
europepmc   +1 more source

Tumor and germline testing with next generation sequencing in epithelial ovarian cancer: a prospective paired comparison using an 18‐gene panel

Molecular Oncology, EarlyView.
Genetic testing in epithelial ovarian cancer includes both germline and tumor‐testing. This approach often duplicates resources. The current prospective study assessed the feasibility of tumor‐first multigene testing by comparing tumor tissue with germline testing of peripheral blood using an 18‐gene NGS panel in 106 patients.
Elisabeth Spenard, Cristina Mitric, Melanie Care, Tracy L. Stockley, Raymond H. Kim, Jeanna McCuaig, Blaise Clarke, Laura Ranich, Clare Sheen, Sarah E. Ferguson, Liat Hogen, Taymaa May, Marcus Q. Bernardini   +12 more
wiley   +1 more source

Research on the Crushing of Reinforced Concrete Two-Way Slabs by Pulse Power Discharge Technology

Buildings
The application of pulse power discharge (PPD) technology in the crushing and dismantling of concrete structures has characteristics related to both green and environmental protection, as well as safety and reliability, with broad application prospects ...
Xinxin Lin, Fei Yang, Youwei Liu, Yang Yang   +3 more
doaj   +1 more source

Effect of the axial load on the dynamic response of the wrapped CFRP reinforced concrete column under the asymmetrical lateral impact load. [PDF]

PLoS One, 2023
Al-Bukhaiti K, Yanhui L, Shichun Z, Abas H, Daguang H, Nan X, Lang Y, Xing Yu Y.   +7 more
europepmc   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Study on dynamic response characteristics of jointed coal mass under impact load

Meikuang Anquan
Based on the similarity theorem, the material ratio of similar coal body is determined, and the single-layer thin-plate coal body is prepared by pouring.
Jianfeng LIU
doaj   +1 more source

Numerical Analyses of Fracture Mechanism of the Pelvic Ring during Side-Impact Load. [PDF]

Materials (Basel), 2022
Klekiel T, Arkusz K, Sławiński G, Malesa P, Będziński R.   +4 more
europepmc   +1 more source

Screening for lung cancer: A systematic review of overdiagnosis and its implications

Molecular Oncology, EarlyView.
Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz, Laura de la Torre‐Perez, David R Baldwin, Carlijn van der Aalst, Mangesh Thorat, David Ritchie, Andre L Carvalho, Carolina Espina, Ivan Solà, Carlos Canelo‐Aybar, Moira Magdalena Pissinis, Pablo Alonso‐Coello, Ana Carolina Pereira Nunes Pinto   +12 more
wiley   +1 more source

Ice-structure impact contact load test setup and impact contact load calculation

, 2014
Shipping in arctic and other ice conditions is increasing. Modern propulsion systems often utilize azimuthing thrusters in their various forms. When operating azimuthing thruster equipped ships in ice conditions, the thruster will interact with ice. One such interaction type is an impact type contact of ice block and thruster.
Kinnunen Aki, Tikanmäki Maria, Koskinen Pekka   +2 more
openaire   +3 more sources