Results 71 to 80 of about 499,828 (261)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Charpy Impact Properties of Hydrogen-Exposed 316L Stainless Steel at Ambient and Cryogenic Temperatures

Metals, 2019
316L stainless steel is a promising material candidate for a hydrogen containment system. However, when in contact with hydrogen, the material could be degraded by hydrogen embrittlement (HE).
Le Thanh Hung Nguyen, Jae-Sik Hwang, Myung-Sung Kim, Jeong-Hyeon Kim, Seul-Kee Kim, Jae-Myung Lee   +5 more
doaj   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Discrete Element Simulations of Fracture Mechanism and Energy Evolution Characteristics of Typical Rocks Subjected to Impact Loads

Applied Sciences
The dynamic fracture behavior of rocks subjected to impact loading is a fundamental issue within the field of rock dynamics. This study aims to construct microstructure models of heterogeneous minerals representative of various typical rocks and ...
Ding Deng, Lianjun Guo, Yuling Li, Gaofeng Liu, Jiawei Hua   +4 more
doaj   +1 more source

Barge’s study under impact loads

IOP Conference Series: Materials Science and Engineering, 2019
Abstract The aim of this paper is to present a method of increasing the safety of inner water navigation. It concern on improving the structural resistance of a barge during design process. Numerical structural analyses of the deck and the board are purposed to solve the problem.
M Nechita, C I Mocanu
openaire   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Crashworthiness Design of Bidirectional Pyramidal Energy-Absorbing Tubes Based on Centipede Structures

Biomimetics
Energy-absorbing components should be effective and stable in engineering protective structure designs to reduce collision impacts. However, conventional energy-absorbing structures have considerable potential for optimization for energy dissipation and ...
Aodi Bie, Xiurong Guo, Danfeng Du, Yuchen Xie   +3 more
doaj   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

A load forecasting method for steel industry based on ICEEMDAN

Zhejiang dianli
In response to the challenge of low accuracy in load forecasting for the steel industry， a load forecasting approach is introduced based on ICEEMDAN （improved complete ensemble empirical mode decomposition with adaptive noise）.
ZHANG Si, LI Yang, WANG Bo, ZHU Geng, HE Xu   +4 more
doaj   +1 more source

Economic Impact of Container-loading Problem

Transactions on Maritime Science, 2020
Thousands of containers with different types of cargo are loaded every day in multiple manufacturing and logistics centres in the world. The main problem arising from these handlings is how to make the maximum use of all the available container capacities, while keeping the overall costs of transport per cargo unit as low as possible.
openaire   +5 more sources