Results 11 to 20 of about 287,814 (303)

Green and sustainable metrics: Charting the course for green-by-design small molecule API synthesis

Current Research in Green and Sustainable Chemistry, 2022
Sustainable small molecule Active Pharmaceutical Ingredient (API) manufacturing starts at the onset of route development by employing a Green-by-Design strategy.
Harrison B. Rose, Birgit Kosjek, Brittany M. Armstrong, Sandra A. Robaire   +3 more
doaj   +1 more source

Synthesis of 4'-C-(aminoethyl)thymidine and 4'-C-[(N-methyl)aminoethyl]thymidine by a new synthetic route and evaluation of the properties of the DNAs containing the nucleoside analogs.

Bioorganic & Medicinal Chemistry, 2022
A gapmer-type antisense oligonucleotide is an oligonucleotide therapeutic that targets pathogenic mRNA directly, and it is expected to be a next-generation therapeutic drug. In this study, we designed and synthesized 4'-C-[(N-methyl)aminoethyl]-thymidine
H. Ueda, Y. Ueno
semanticscholar   +1 more source

Synthetic Route to Conjugated Donor–Acceptor Polymer Brushes via Alternating Copolymerization of Bifunctional Monomers

Polymers, 2022
Alternating donor–acceptor conjugated polymers, widely investigated due to their applications in organic photovoltaics, are obtained mainly by cross-coupling reactions.
Anna Grobelny, Karolina Lorenc, Łucja Skowron, S. Zapotoczny   +3 more
semanticscholar   +1 more source

Efficient pilot-scale synthesis of the key cefonicid intermediate at room temperature

Green Processing and Synthesis, 2022
Cefonicid is a common second-generation cephalosporin, and the 7-amino-3-[sulphomethyl-1-H-tetrazol-5-yl-thiomethyl]-3-cephem-4-carboxylate monosodium salt is a key synthetic intermediate in its preparation.
Comito Marziale, Monguzzi Riccardo, Tagliapietra Silvia, Palmisano Giovanni, Cravotto Giancarlo   +4 more
doaj   +1 more source

The Economic Impact of Payments for Water-related Ecosystem Services on Protected Areas: a Synthetic Control Analysis

Water resources management, 2021
Payments for Water-Related Ecosystem Services (PWES) are increasingly popular for promoting water ecological conservation, and their impact on development is of considerable interest.
Jianmei Zhang, Jiwei Zhu, Yu Liu, Nancy Lu, W. Fang   +4 more
semanticscholar   +1 more source

Synthesis of N-Doped Few-Layer Graphene through Shock-Induced Carbon Fixation from CO₂

Nanomaterials, 2022
In this study, graphene and N-doped graphene nanosheets were synthesized through the shock-induced reduction of CO2 using a cylindrical shock-loading apparatus.
Hao Yin, Xin Gao, Jianjun Liu, Pengwan Chen   +3 more
doaj   +1 more source

Mechanochemistry Frees Thiourea Dioxide (TDO) from the ‘Veils’ of Solvent, Exposing All Its Reactivity

Molecules, 2023
The synthesis of nitrogen-based heterocycles has always been considered essential in developing pharmaceuticals in medicine and agriculture. This explains why various synthetic approaches have been proposed in recent decades.
Francesco Basoccu, Federico Cuccu, Pietro Caboni, Lidia De Luca, Andrea Porcheddu   +4 more
doaj   +1 more source

Combining pot, atom and step economy (PASE) in organic synthesis. Synthesis of tetrahydropyran-4-ones [PDF]

, 2007
The combination of pot, atom and step economy (PASE) in the synthesis of organic molecules of medium complexity can lead to a significant 'greening' of a synthetic route.
Clarke, Paul A., Martin, William H. C., Santos, Soraia   +2 more
core   +1 more source

Synthesis and Antileishmanial Activity of 1,2,4,5-Tetraoxanes against Leishmania donovani [PDF]

, 2020
A chemically diverse range of novel tetraoxanes was synthesized and evaluated in vitro against intramacrophage amastigote forms of Leishmania donovani. All 15 tested tetraoxanes displayed activity, with IC50 values ranging from 2 to 45 µm.
Amado, Patrícia, Cabral, Lília, Cojean, Sandrine, Cristiano, Maria De Lurdes, Loiseau, Philippe M., Pomel, Sébastien   +5 more
core   +1 more source

Functionalization of Pyrene To Prepare Luminescent Materials—Typical Examples of Synthetic Methodology [PDF]

, 2016
Pyrene-based π-conjugated materials are considered to be an ideal organic electro-luminescence material for application in semiconductor devices, such as organic light-emitting diodes (OLEDs), organic field-effect transistors (OFETs) and organic ...
Ajami, Alfonso, Baldo, Barton, Batsanov, Beaupré, Beller, Bernhardt, Bolm, Cao, Caronna, Caronna, Casas-Solvas, Cerfontain, Chang, Chen, Chen, Cheng, Chercka, Coventry, Crawford, Dewar, Duong, Eliseeva, Espinosa, Feng, Feng, Feng, Feng, Feng, Feng, Feng, Figueira-Duarte, Figueira-Duarte, Figueira-Duarte, Fihri, Fuchibe, Gao, García, Gonell, Grandbois, Hashmi, Hong, Hu, Hu, Hu, Hu, Hu, Hu, Hu, Hu, Hu, Hu, Ibáñez, Inoue, Irvine, Ito, Iwasaki, Jeon, Ji, Ji, Jiang, Jiao, Kamtekar, Katz, Kawano, Keller, Kim, Kim, King, Klauk, Kohl, Kulisic, Kumar, Lambert, Lee, Lee, Letizia, Li, Li, Liu, Malashikhin, Marco, Mateo-Alonso, Miyasaka, Miyaura, Miyaura, Miyazawa, Miyazawa, Mkhalid, Moorthy, More, More, Moulin, Ni, Niko, Oberender, Olah, Olah, Paul, Qiao, Rajca, Rajca, Rathore, Reineke, Schmidt-Mende, Sonar, Sun, Sun, Szaciłowski, Tan, Tanaka, Tang, Tao, Tashiro, Thomas, Trattnig, Trattnig, Valdés, Venkataramana, Verbiest, Verbiest, Visbal, Vollmann, Xiao, Xu, Yamato, Yamato, Yamato, Yamato, Yamato, Yua, Zak, Zhang, Zhang, Zhao, Zwijnenburg, Zöphel, Zöphel, Zöphel   +139 more
core   +2 more sources