Results 101 to 110 of about 25,605,949 (420)
Ion channel function of polycystin‐2/polycystin‐1 heteromer revealed by structure‐guided mutagenesis
FEBS Letters, EarlyView.Mutations in polycystin‐1 (PC1) or polycystin‐2 (PC2) cause autosomal‐dominant polycystic kidney disease (ADPKD). We generated a novel gain‐of‐function PC2/PC1 heteromeric ion channel by mutating pore‐blocking residues. Moreover, we demonstrated that PC2 will preferentially assemble with PC1 to form heteromeric complexes when PC1 is co‐expressed ...
Tobias Staudner +7 more
wiley +1 more source
Impact of dynamical chiral symmetry breaking on meson structure and interactions [PDF]
, 2010 We provide a glimpse of recent progress in meson physics made via QCD's Dyson-Schwinger equations with: a perspective on confinement and dynamical chiral symmetry breaking (DCSB); a pre'cis on the physics of in-hadron condensates; results for the masses ...
C. D. ROBERTS +4 more
core +2 more sources
The impact of protein characterization in structural proteomics [PDF]
Acta Crystallographica Section D Biological Crystallography, 2006 Protein characterization plays a role in two key aspects of structural proteomics. The first is the quality assessment of the produced protein preparations. Obtaining well diffracting crystals is one of the major bottlenecks in the structure-determination pipeline.
Geerlof, Arie +15 more
openaire +7 more sources
Autophagy in cancer and protein conformational disorders
FEBS Letters, EarlyView.Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley +1 more source
The economic impact of demographic structure in OECD countries [PDF]
, 2012 We examine the impact of demographic structure, the proportion of the population in each age group, on growth, savings, investment, hours, interest rates and inflation using a panel VAR estimated from data for 20 OECD economies, mainly for the period ...
Aksoy, Yunus +2 more
core
Structural record of an oblique impact
Earth and Planetary Science Letters, 2006 Abstract Most impactors strike their target at an oblique angle. The common criterion for identifying craters formed by an oblique impact is the pattern of the ejecta blanket. On Earth, however, ejecta blankets are rarely preserved and other morphological, structural or geophysical criteria are needed.
Scherler, D., Kenkmann, T., Jahn, A.
openaire +5 more sources
Knottin cyclization: impact on structure and dynamics [PDF]
BMC Structural Biology, 2008 Abstract Background Present in various species, the knottins (also referred to as inhibitor cystine knots) constitute a group of extremely stable miniproteins with a plethora of biological activities. Owing to their small size and their high stability, knottins are considered as excellent leads or scaffolds in drug ...
Laurent Chiche +11 more
openaire +5 more sources
A stepwise emergence of evolution in the RNA world
FEBS Letters, EarlyView.How did biological evolution emerge from chemical reactions? This perspective proposes a gradual scenario of self‐organization among RNA molecules, where catalytic feedback on random mixtures plays the central role. Short oligomers cross‐ligate, and self‐assembly enables heritable variations. An event of template‐externalization marks the transition to
Philippe Nghe
wiley +1 more source
FEBS Letters, EarlyView.The enzyme 5‐lipoxygenase (5‐LOX) catalyzes the first step in the biosynthesis of leukotrienes (LTs) involved in inflammatory pathophysiology. After cellular stimulation, 5‐LOX translocates to the nucleus, interacting with the 5‐LOX‐activating protein (FLAP) to form LTA4 from arachidonic acid (AA).
Erik Romp +5 more
wiley +1 more source
Surfaceome: a new era in the discovery of immune evasion mechanisms of circulating tumor cells
Molecular Oncology, EarlyView.In the era of immunotherapies, many patients either do not respond or eventually develop resistance. We propose to pave the way for proteomic analysis of surface‐expressed proteins called surfaceome, of circulating tumor cells. This approach seeks to identify immune evasion mechanisms and discover potential therapeutic targets. Circulating tumor cells (
Doryan Masmoudi +3 more
wiley +1 more source