Results 91 to 100 of about 1,754,919 (302)

Insulin sensitivity regulates cholesterol metabolism to a greater extent than obesity: lessons from the METSIM Study1

Journal of Lipid Research, 2010
Cholesterol synthesis is upregulated and absorption downregulated in insulin resistance and in type 2 dia-betes. We investigated whether alterations in cholesterol metabolism are observed across the glucose tolerance status, from normoglycemia through ...
Helena Gylling, Maarit Hallikainen, Jussi Pihlajamäki, Piia Simonen, Johanna Kuusisto, Markku Laakso, Tatu A. Miettinen   +6 more
doaj   +1 more source

Impaired fasting glucose and impaired glucose tolerance in rural population of Bangladesh

Bangladesh Medical Research Council Bulletin, 1970
The prevalence of type 2 diabetes is rapidly rising all over the world at an alarming rate. Over the past 30 years, the increase in prevalence is rising exponentially in South Asian region, data suggest a three fold increase (from 2.0 to 7.0%) in the urbanizing population of Bangladesh within 5 years.
Muhammad Abdur Rahim, Abul Kalam Azad Khan, Quamrun Nahar, S Ali, Akhtar Hussain   +4 more
openaire   +3 more sources

Effect of Apple Consumption on Postprandial Blood Glucose Levels in Normal Glucose Tolerance People versus Those with Impaired Glucose Tolerance

, 2022
The present study investigated the effect of apple consumption on postprandial blood glucose and insulin levels in subjects with normal versus impaired glucose tolerance.
Inoue, Yutaka, Yoshimura, Kana, Sano, Aiko, Ryuichiro Suzuki, Kana Yoshimura, Aiko Sano, Hori, Yumiko, Kanamoto, Ikuo, Yutaka Inoue, Ikuo Kanamoto, Yumiko Hori, Suzuki, Ryuichiro, Lianne Cormanes, Cormanes, Lianne   +13 more
core   +1 more source

Phosphorylation‐Facilitated CKB Lactylation At K11 By GCN5 Enhances Creatine Kinase Activity and Mitigates Neuronal Damage After Cerebral Ischemia‐Reperfusion

Advanced Science, EarlyView.
This study uncovers hierarchical coordination between K11 lactylation and S199 phosphorylation of CKB in cerebral ischemia‐reperfusion injury. Such dual modifications potentiate CKB enzymatic function, remodel energy metabolism, alleviate oxidative stress and neuronal damage, and represent a viable therapeutic target for stroke treatment.
Chao Duan, Ruolin Zhang, Shihui Ding, Ying Feng, Tao Shen, Ziwei Wang, Wendai Bao, Ke Shui, Jun Qin, Jun Chen, Min Zhang, Zijing Ren, Dongmei Zhao, Xingrong Guo, Zhibing Ai, Xin Yang, Peiyang Zhou, Zhiqiang Dong   +17 more
wiley   +1 more source

Modulation of miR‐23b Wnt/β‐catenin Axis Strengthens Endothelial Barrier Properties

Advanced Science, EarlyView.
Early blood‐brain barrier (BBB) disruption contributes to stroke and CNS disease pathology. miR‐23b was identified as a regulator of BBB integrity in brain endothelial cells. Inhibition of miR‐23b enhanced barrier‐associated properties, promoted repair‐related signaling, and reduced BBB leakage in experimental stroke models, supporting further ...
Victor Anthony Martinez, Rose E. Presby, Sara Nakanishi, Pallavi Gaur, Ugur Akcan, Johannes Daugaard Krog, Iben Daugaard Krog, Lipi Das, David S. Johnson, Danny Jamoul, Douglas Jury, Brian Lawson, Jacob Körbelin, Lewis M. Brown, Vilas Menon, Dritan Agalliu, Irene Munk Pedersen   +16 more
wiley   +1 more source

Occurrence and predictors of persistent impaired glucose tolerance after acute ischemic stroke or transient ischemic attack [PDF]

, 2014
Background Impaired glucose tolerance is often present in patients with a transient ischemic attack (TIA) or ischemic stroke and doubles the risk of recurrent stroke.
Hertog, H.M. (Heleen) den, Hertog, Heleen, Fonville, Susanne, Koudstaal, P.J. (Peter), Zandbergen, A.A.M. (Adrienne), Lingsma, H.F. (Hester), Koudstaal, Peter, Lingsma, Hester, Zandbergen, AAM (Adrienne)   +8 more
core   +1 more source

Engineering Immunoregenerative Therapy via an Immunomodulatory Binary Pharmacology Hydrogel Depot for Prolonged Allograft Survival

Advanced Science, EarlyView.
An immunomodulatory hydrogel (iGEL) forms spontaneously upon subcutaneous injection, acting as a tissue‐adhesive depot. It releases anti‐rejection and regenerative agents in response to inflammation, suppressing T‐cell activity, promoting vascular repair, and restoring allograft function without systemic immunosuppression.
Ning Wang, Ruiqi Sun, Yang Fu, Zhonghan Wu, Xinyu Tong, Hong Tang, Wentao Zhao, Zhi Liang, Jintao Zheng, Yanan Guan, Ke Zhou, Penghong Song, Shusen Zheng, Hangxiang Wang, Haiyang Xie   +14 more
wiley   +1 more source

Sensitivity of postnatal fasting plasma glucose in identifying impaired glucose tolerance in women with gestational diabetes-25 year’s data [PDF]

, 2017
Objective - To assess the uptake of postnatal oral glucose tolerance test and to determine the sensitivity of fasting postnatal blood sugar in predicting 2-h impaired glucose tolerance.
Kapaya, H., Priya Madhuvrata, Madhuvrata, P., Habiba Kapaya, May, L., Jacques, R., Richard Jacques, Lucy May   +7 more
core   +1 more source

Single‐Cell Dissection of Therapy‐Induced Remodeling Uncovers a Fibroblast‐Driven Immunosuppressive Niche and Targetable Vulnerabilities in Lethal Prostate Cancer

Advanced Science, EarlyView.
Single‐cell longitudinal profiling reveals that androgen‐deprivation therapy induces a DPT+ fibroblast‐complement axis that suppresses macrophage inflammation and drives CD8+ T cell exhaustion in prostate cancer. Concurrently, resistant epithelial subpopulations persist and engage TSPAN1‐ and NRXN1‐mediated programs promoting CRPC and neuroendocrine ...
Yang Chen, Dandan Dong, Jinling Liao, Naikai Liao, Mengqi Liu, Qin Zhang, Siting Chen, Qi Liu, Ying Lu, Tianyu Li, Chunlin Zou, Qiong Song, Qiuyan Wang, Jian Liang, Qiji Xie, Chengyang Li, Mengyun Wang, Jiwen Cheng, Zengnan Mo, Gong‐Hong Wei   +19 more
wiley   +1 more source

The efficacy of interventions to prevent type 2 diabetes among women with recent gestational diabetes mellitus—A living systematic review and meta‐analysis

Journal of Diabetes
Background While previously considered a transient condition, with no lasting adverse impact, gestational diabetes mellitus (GDM) is now a well‐established risk factor for developing type 2 diabetes mellitus (T2DM). The risk of developing T2DM appears to
Vivian Y. Lee, Mohammad R. Monjur, Joseph Alvin Santos, Anushka Patel, Rong Liu, Gian Luca Di Tanna, Yashdeep Gupta, Alpesh Goyal, Saumiyah Ajanthan, Devarsetty Praveen, J. K. Lakshmi, H. Asita deSilva, Nikhil Tandon   +12 more
doaj   +1 more source