Results 111 to 120 of about 1,754,919 (302)

Metabolic abnormalities in impaired glucose tolerance

Metabolism, 1997
Impaired glucose tolerance (IGT) is a state in which there is postprandial hyperglycemia (> 7.8 mmol/L, or 140 mg/dL) with minimal elevations of fasting plasma glucose (> 5.5 < 7.8 mmol/L, > 100 < 140 mg/dL). This condition generally precedes the development of diabetes mellitus (DM) by several years. However, in IGT many of the metabolic abnormalities
openaire   +2 more sources

The Impact of glucose and glucoregulation on memory [PDF]

The effect of glucose on memory has been investigated for in excess of 25 years, with some consensus generated amongst the literature indicating that glucose has a facilitating effect.
Elliott, Jade
core  

Primary care screening for individuals with impaired glucose metabolism with focus on impaired glucose tolerance

, 2015
Aim: To evaluate the utility of three short questions (the Skövde Form) combined with a random plasma glucose, and HbA1c as alternative tools for detection of individuals with impaired glucose metabolism (IGM), and particularly impaired glucose tolerance
Hellgren, Margareta,, Jansson, Per-Anders,, Daka, Bledar,, Lindblad, Ulf,   +3 more
core   +1 more source

Remote Magnetomechanical Neuromodulation Uncovers Therapeutic Mechanisms for Alleviating Parkinsonian Symptoms in Freely Moving Mice

Advanced Science, EarlyView.
Magnetomechanical neuromodulation using magnetic nanodiscs enables remote activation of neurons. In a hemiparkinsonian mouse model, alternating magnetic fields actuate the nanodiscs to generate torque that opens mechanosensitive ion channels within the subthalamic nucleus, thereby modulating basal ganglia motor circuitry.
Anouk Wolters, Lorenzo Signorelli, Christian Herff, Sophia Gimple, Renzo Riemens, Gunter Kenis, Kim Rijkers, Hamed Shabani, Jyh‐Jang Sun, Yasin Temel, Hans Clusmann, Danijela Gregurec, Sarah‐Anna Hescham   +12 more
wiley   +1 more source

Gene Correction Enhances Dopaminergic Cell Therapy in a Nonhuman Primate Model of Parkinson's Disease

Advanced Science, EarlyView.
LRRK2‐mutant induced pluripotent stem cells (iPSCs) were derived from a patient with Parkinson's disease (PD). Using CRISPR/Cas9–mediated gene editing, the pathogenic LRRK2 mutations were precisely corrected, and isogenic dopaminergic neural progenitor cells (DA‐NPCs) were subsequently generated.
Qing Yan, Chongchong Xu, Jiangmei Gao, Pu Wang, Qingling Wu, Ying Jin, Binyan Lu, Mu Li, Mingting Shao, Bihai Li, Zhenghui Su, Yijng Zhang, Jianhuan Chen, Haojie An, Mengyao Huang, Xiaoji Zhuang, Yuhui Shen, Fenglin Wang, Nana Xu, Yiyan Liu, Lei Tang, Xiuling Zhong, Minyan Zhong, Jiecong Chen, Zhenhuang Wang, Xingrong Luo, Sheng Liu, RuiFeng Liu, Ling Zhang, Junhua Rao   +29 more
wiley   +1 more source

A Printed Hydrogel Hybrid Electronic System With Thermoresponsive Adhesion for Neurophysiological Monitoring

Advanced Science, EarlyView.
This work develops a soft hybrid electronic system with printed thermoresponsive hydrogel electrodes, which enables high‐fidelity neural signal acquisition and stimulation. The system precisely assesses median and ulnar nerve injuries in clinical cases, realizing accurate diagnosis of neural impairment while ensuring customized adhesion regulation ...
Bo Pang, Ganguang Yang, Jiacheng Wen, Hangyu Gong, Caixin Gong, Yuqi Qiu, Zhixin Wang, Qingyang Zheng, Sen Zhou, Tianzhao Bu, Jia Tian, Zhouping Yin, Yutian Liu, Hao Wu   +13 more
wiley   +1 more source

Gestational age, birth weight, and perinatal complications in mothers with diabetes and impaired glucose tolerance: Japan Environment and Children’s Study cohort [PDF]

We aimed to determine the risk of perinatal complications during delivery in mothers with non-normal glucose tolerance in a large Japanese birth cohort. We analysed data of 24,295 neonate-mother pairs in the Japan Environment and Children's Study cohort ...
25509, Ooka, Tadao, 24695, Horiuchi, Sayaka, コジマ, レイジ, the Japan Environment and Children’s Study Group, 24690, 小田和, 早苗, 24294, クシマ, メグミ, ヤマガタ, ゼンタロウ, ヨコミチ, ヒロシ, 久島, 萌, 24901, 10210337, 00807646, 篠原, 亮次, 25039, 25512, 望月, 美恵, 00633116, 山縣, 然太朗, Mochizuki, Mie, モチヅキ, ミエ, 小島, 令嗣, シノハラ, リョウジ, Otawa, Sanae, オオオカ, タダオ, 40422688, Yokomichi, Hiroshi, 大岡, 忠生, 24631, 23302, 24118, Miyake, Kunio, Akiyama, Yuka, 20596879, ホリウチ, サヤカ, 10523780, 堀内, 清華, ミヤケ, クニオ, Kojima, Reiji, オタワ, サナエ, 60550712, 横道, 洋司, Yamagata, Zentaro, 40803987, Kushima, Megumi, 三宅, 邦夫, Shinohara, Ryoji   +49 more
core   +1 more source

Biomimetic Nanoplatform for Dual Target Nano‐Metabolic Therapy in Diabetes‐Associated Biofilm Infections

Advanced Science, EarlyView.
A biomimetic GOx/Arg‐loaded nanoplatform produces nitric oxide through an in situ catalytic cascade reaction, enabling dual‐target metabolic regulation in diabetes‐associated biofilm infections. Bacterial metabolism is disrupted, and macrophage immunometabolism is reprogrammed, resulting in biofilm eradication, immune restoration, and enhanced ...
Mingzhang Li, Yonglong Li, Jiren Yan, Changming Wang, Jinlong Yu, Feng Jiang, Boyong Wang, Yi Yang, Deyi Ding, Jin Tang, Pei Han, Botao Song, Geyong Guo, Hao Shen   +13 more
wiley   +1 more source

Importance of OGTT for diagnosis of Diabetes in thalassemia major patients

مجله دانشگاه علوم پزشکی گرگان, 2008
Background and Objective: Thalassemia major is a genetic disorder. Blood transfusion is critical for survival in these patients. Over the course of the past two and three decade’s hyper transfusion therapy in these patients has increased significant ...
Farzad Najafipour (MD), Roohangiz Sari Sorkhabi (MD), Navideh Haji Aghai (GP), Masoomeh Zareizadeh (MD), Amir Bahrami (MD)   +4 more
doaj  

Bioengineered Exosome‐Loaded Immunomodulatory Bioadhesive Spray Reverses Liver Fibrosis and Metabolic Dysfunction That Triggers Beneficial Gut‐Liver Crosstalk in Chronic Fatty Liver Disease

Advanced Science, EarlyView.
Umbilical cord stem cell‐derived exosomes encapsulated in an immunomodulatory bioadhesive hydrogel spray enable localized therapy, sustained vesicle delivery, macrophage polarization, suppress systemic inflammation, and mitigate glucose and insulin homeostasis impairments in MAFLD.
Triya Saha, Ayushi Mairal, Shreya Mehrotra, Shiv K. Sarin, Ashok Kumar   +4 more
wiley   +1 more source