Results 121 to 130 of about 1,760,363 (317)

Screwing the Social Model of Disability

open access: yesScandinavian Journal of Disability Research
The social model of disability represents the disability movements ‘big idea’, and since its formulation, it has received sustained appraise and critique.
Ryan Thorneycroft
doaj   +1 more source

Ubiquitination of secretory granules promotes their crinophagic degradation in Drosophila

open access: yesFEBS Letters, EarlyView.
Ubiquitination of secretory granules in Drosophila larval salivary glands is a critical molecular trigger for crinophagy, the lysosomal degradation of unreleased, or low‐quality granules. The E3 ubiquitin ligase Cnot4 is recruited to the surface of secretory granules to induce crinophagy.
Tamás Csizmadia   +6 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

The effect of Asset Impairment (IAS 36) in Improving the Quality of Accounting Information According to Users’ Perspective: Evidence from Jordan [PDF]

open access: yes, 2013
Purpose: The main purpose of this study is to investigate from the users' perspective the influence of adopting IAS 36 'impairment of assets' on accounting information in Jordan and to ascertain the extent to which impairment application can affect ...
KANAKRIYAH, RAED,MUHAMMAD
core  

Global estimates on the number of people blind or visually impaired by Uncorrected Refractive Error: a meta-analysis from 2000 to 2020 [PDF]

open access: yes
Background: Uncorrected refractive error (URE) is a readily treatable cause of visual impairment (VI). This study provides updated estimates of global and regional vision loss due to URE, presenting temporal change for VISION 2020 Methods: Data from ...
Vision Loss Expert Group of the Global Burden of Disease Study,   +5 more
core   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

open access: yesMolecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano   +6 more
wiley   +1 more source

An Applied Pragmatic Perspective of Autism in The Medical Interactions in TV Series: ‘The Good Doctor'

open access: yesآداب الكوفة
Sperber & Wilson (2005:468) see Pragmatics as is " the study of how contextual factors interact with linguistic meaning in the interpretation of utterances". Doctors often recognize patterns in people’s speech from their utterances.
طالب علي, حسن الكعبي
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

Screwing With Our Embodiment: A Response to Thorneycroft’s Re-Imagining of the Social Model

open access: yesScandinavian Journal of Disability Research
This paper presents a response to Thorneycroft’s (2024) proposed conceptual solution to the disability-impairment binary at the heart of the social model of disability, also published in this journal.
Brian Watermeyer, Clare Harvey
doaj   +1 more source

Functional impairment in South African children and adolescents with obsessive-compulsive disorder

open access: yes, 2009
Includes bibliographical references (leaves 109-115).This research aimed to increase current understanding of functional impairment in children and adolescents with Obsessive-Compulsive Disorder (OCD).
Hoppe, Lara Judy
core  

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