Results 101 to 110 of about 575,905 (318)
Mild Cognitive Impairment [PDF]
New England Journal of Medicine, 2004 As individuals age, the quality of cognitive function becomes an increasingly important topic. The concept of mild cognitive impairment (MCI) has evolved over the past 2 decades to represent a state of cognitive function between that seen in normal aging and dementia.
openaire +2 more sources
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
Impairments in 'theory of mind' shortly after traumatic brain injury and at one-year follow-up
, 2006 Most studies into acquired theory of mind (ToM) deficits assessed patients once, long after the onset of brain injury. As a result, the time course of acquired ToM impairments is largely unknown.
Crawford, John R +4 more
core +1 more source
Communicating mild cognitive impairment diagnoses with and without amyloid imaging
Alzheimer’s Research & Therapy, 2017 Background Mild cognitive impairment (MCI) has an uncertain etiology and prognosis and may be challenging for clinicians to discuss with patients and families.
Joshua D. Grill +17 more
doaj +1 more source
FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
Motor Impairments in Autism Spectrum Disorder: Implications for Intervention and Research
Motor impairments, such as unusual posture, are a critical aspect of autism spectrum disorder (ASD) that affects individuals of all ages and influences how the disorder manifests.
Bryan V. Catama
core +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Revisiting the Strange Stories: Revealing Mentalizing Impairments in Autism
, 2009 A test of advanced theory of mind (ToM), first introduced by F. Happé (1994), was adapted for children (mental, human, animal, and nature stories plus unlinked sentences).
White, Sarah +4 more
core +1 more source
Dual task impairments in vascular dementia [PDF]
, 2010 Several studies have shown that people with Alzheimer's disease (AD) demonstrate difficulties in doing two things at once or 'dual-tasking' and that this dual task impairment is insensitive to normal ageing, chronic depression or prodromal conditions ...
Della Sala, Sergio +11 more
core +1 more source