Results 111 to 120 of about 877,222 (332)

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

open access: yesMolecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou   +5 more
wiley   +1 more source

Wake and Impedance

open access: yes, 2000
A systematic exposition of the basic concepts of wakes and impedances is given for relativistic beams in accelerators.Comment: Lecture presented at JAS'2000 Accelerator School On Frontiers Of Accelerator Technology: High Quality Beams, St. Petersburg -
Stupakov, G. V.
core   +2 more sources

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham   +21 more
wiley   +1 more source

Stable determination of the surface impedance of an obstacle by far field measurements

open access: yes, 2005
We deal with the inverse scattering problem of determining the surface impedance of a partially coated obstacle.
Sincich, Eva
core   +2 more sources

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

open access: yesMolecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan   +9 more
wiley   +1 more source

Determining acoustical directionality in an impedance tube using multiple fixed microphones [PDF]

open access: yes, 2011
Acoustic impedance of a port or object is a valuable piece of knowledge describing how well sound is transmitted or reflected. The commonly used slotted-line method is labourious and time consuming, requiring manual movement to find the maxima and minima
Bodman, Kerry   +2 more
core   +1 more source

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira   +14 more
wiley   +1 more source

Loading Effect of W-band Resonant Tunneling Diode Oscillator by Using Load-Pull Measurement [PDF]

open access: yes, 2017
Resonant tunneling diode (RTD) is the fastest solid-state electronic device with the highest reported frequency at 1.92 THz [1]. RTD-based THz sources have many promising applications such as ultrafast wireless communications, THz imaging, etc.
Al-Khalidi, Abdullah   +6 more
core  

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

open access: yesMolecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath   +13 more
wiley   +1 more source

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