Results 51 to 60 of about 28,996 (260)

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

A new simple method for determining the sound absorption coefficient

MATEC Web of Conferences, 2018
Taking into account the influence of the length and diameter of the impedance tube on the process of decay of sound waves, a new study of sound propagation in an impedance tube is presented, on the basis of which it is easier to determine the sound ...
Chelidze Merab
doaj   +1 more source

Impedance Tube Solution for Helmholtz Resonator Prototyping

Acoustics Australia
Abstract Transfer function method impedance tube measurement is a well-known approach used for determining acoustical properties of mostly porous materials. This paper presents a prototype of impedance tube together with the software solution published under open-source license.
Jun, David, Plasek, Josef
openaire   +3 more sources

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

FOAM 02: A dataset of impedance tube measurements with different materials and diameter variations

Acta Acustica
Impedance tube measurements are a widespread method for determining the sound absorption coefficient (SAC) of porous materials for normal sound incidence. The measurement method is standardised in ISO 10534-2.
Caiazzo Alfonso, Kraxberger Florian, Wurzinger Andreas, Boysen Jan, Petrone Giuseppe, Schoder Stefan, De Rosa Sergio, Kaltenbacher Manfred, Adams Christian   +8 more
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Angle-Dependent Absorption of Sound on Porous Materials

Acoustics, 2020
Sound-absorbing materials are usually measured in a reverberation chamber (diffuse field condition) or in an impedance tube (normal sound incidence). In this paper, we show how angle-dependent absorption coefficients could be measured in a factory-type ...
Jose Cucharero, Tuomas Hänninen, Tapio Lokki   +2 more
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Investigations on Sound Absorption Properties of Luffa Fibrous Mats

Journal of Natural Fibers, 2018
In this study, the natural fibrous mats were developed using luffa fibrous materials and their sound absorption properties were investigated. Kapok/cotton web was used as middle layer in between two mats in order to improve the sound absorption ...
G. Thilagavathi, S. Neela Krishnan, N. Muthukumar, Santhana Krishnan   +3 more
doaj   +1 more source