Results 71 to 80 of about 1,426,001 (339)

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

Thermo-mechanical Loading of Laminates with Imperfect Interfaces

Procedia Engineering, 2014
AbstractComposite laminates are currently being pursued for structures which may be subjected to explosive threats in aggressive environments, characterized by extreme temperatures and seawater. A mechanical model is formulated for laminated plates subjected to thermo-mechanical loading and deforming in cylindrical bending; the layers are assumed to be
MASSABO', ROBERTA, CAMPI, FRANCESCA
openaire   +2 more sources

FEM-BEM modeling of dynamic responses of saturated soil around fluid-filled lined tunnel with imperfect soil-lining interface under water hammer

Yantu gongcheng xuebao
This study employs the Finite Element Method-Boundary Element Method (FEM-BEM) to simulate the dynamic response of saturated soil around a fluid-filled circular tunnel under water hammer loading, accounting for imperfect bonding at the soil-lining ...
FU Yiming 1, HUANG Chao 3, QIAN Jiangu 1, 2
doaj   +1 more source

The multifaceted roles of lysosomes in cancer

Molecular Oncology, EarlyView.
Lysosomes support cancer cell adaptation by integrating macromolecule degradation and nutrient recycling with nutrient sensing, inter‐organelle communication and immune regulation. These interconnected functions can promote tumour growth, stress tolerance and therapy resistance, while also creating context‐dependent vulnerabilities that may be ...
Jia Li, Kevin M. Ryan
wiley   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Protein docking prediction using predicted protein-protein interface

BMC Bioinformatics, 2012
Background Many important cellular processes are carried out by protein complexes. To provide physical pictures of interacting proteins, many computational protein-protein prediction methods have been developed in the past. However, it is still difficult
Li Bin, Kihara Daisuke
doaj   +1 more source

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

FEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss, Ao Li, Eduardo H. Gilglioni, Mayank Bansal, Sumeet Pal Singh, Latifa Bakiri, Alessandra K. Cardozo, Esteban N. Gurzov   +7 more
wiley   +1 more source

Influence of Flexoelectric Coupling and Interfacial Imperfection on Shear Horizontal Wave Propagation in a Piezoflexoelectric Layer over an Elastic Substrate

Mathematics
This study analytically investigates shear horizontal (SH) wave propagation in a layered structure consisting of a piezoflexoelectric (PFE) layer bonded to an elastic substrate, considering an imperfect interface.
Ayman Alneamy, Kulandhaivel Hemalatha, Mohammed Tharwan   +2 more
doaj   +1 more source

A new flow chip in combination with multiphoton microscopy as a protocol for longitudinal 3D imaging of tissue calcification under shear stress

FEBS Open Bio, EarlyView.
Miniaturized flow chip platform enabling continuous perfusion and longitudinal multiphoton 3D imaging of vascular smooth muscle cell constructs under physiological flow. Brightfield imaging guides region selection, while CellTracker Green and mRuby‐labeled fetuin‐A visualize cells and mineral deposition, respectively. Magnesium supplementation markedly
Vytautas Kučikas, Aaron D. Morgan, Ignas Čiurlionis, Christian Böhm, Stefan Jockenhövel, Willi Jahnen‐Dechent, Marc A. M. J. van Zandvoort   +6 more
wiley   +1 more source

Composites with imperfect interface

, 1995
Lipton, R.; Vernescu, B.. (1995). Composites with imperfect interface.
Lipton, R., Vernescu, B.
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