Results 41 to 50 of about 6,004 (259)

Multiscale Analysis of Composite Structures

Biomath, 2012
The goal of this paper is to present some homogenization results for diffusion problems in composite structures, formed by two media with different features.
Claudia Timofte
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Characteristics of SH waves in multilayered piezoelectric semiconductor plates considering interfacial imperfection

Archives of Mechanics
The dispersion and attenuation characteristics of SH waves in piezoelectric semiconductor multilayered plates with imperfect interfaces are investigated using the improved Legendre orthogonal polynomial method.
Y.H. Luo, X.M. Zhang, A.R. Gao
doaj   +1 more source

An Improved Micromechanical Framework for Saturated Concrete Repaired by the Electrochemical Deposition Method considering the Imperfect Bonding

Journal of Engineering, 2016
The interfaces between the deposition products and concrete are not always well bonded when the electrochemical deposition method (EDM) is adopted to repair the deteriorated concrete.
Qing Chen, Zhengwu Jiang, Hehua Zhu, J. Woody Ju, Zhiguo Yan, Yaqiong Wang   +5 more
doaj   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Homogenization and exact controllability for problems with imperfect interface

Networks & Heterogeneous Media, 2019
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Monsurro S., Perugia C.
openaire   +4 more sources

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Tough Nature-Inspired Helicoidal Composites with Printing-Induced Voids

Cell Reports Physical Science, 2020
Summary: Exoskeletons of Odontodactylus japonicas, the “smasher-type” mantis shrimp, feature a raptorial appendage comprising a Bouligand architecture of chitin nanofibrils with newly observed voids or defects between the polysaccharide α-chitin and ...
Sha Yin, Haoyu Chen, Ruiheng Yang, Qinghao He, Dianhao Chen, Lin Ye, Yiu-Wing Mai, Jun Xu, Robert O. Ritchie   +8 more
doaj   +1 more source

Non-comoving cold dark matter in a $$\varLambda $$ Λ CDM background

European Physical Journal C: Particles and Fields, 2021
We examine the evolution of peculiar velocities of cold dark matter (CDM) in localized arrays of inhomogeneous cosmic structures in a $$\varLambda $$ Λ CDM background that can be identified as a frame comoving with the Cosmic Microwave (CMB).
Sebastián Nájera, Roberto A. Sussman
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source