Results 51 to 60 of about 641,475 (292)

Prospecting the protein design landscape

FEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona, Katharina T. Stonig, Jens Meiler, Clara T. Schoeder, Monica L. Fernández‐Quintero   +4 more
wiley   +1 more source

Imperfect information: information sets and sub-game perfection [Game theory]

, 2016
Educação Superior::Ciências Sociais Aplicadas::EconomiaPresents a class about imperfect information on Economics. In games, the person has consider that exist both simultaneous and sequential components, combining ideas from before and after the midterm.
Polak, Ben
core   +2 more sources

3D elastic neutral inclusions with imperfect interfaces [PDF]

, 2002
International audienceUsing a physically-based constitutive law for imperfect. interfaces, this work deals with the problem of embedding a three-dimensional elastic inclusion in a uniformly stressed elastic matrix without changing the initial stress ...
Qi-Chang He, He, Qi-Chang
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Tough Nature-Inspired Helicoidal Composites with Printing-Induced Voids

Cell Reports Physical Science, 2020
Summary: Exoskeletons of Odontodactylus japonicas, the “smasher-type” mantis shrimp, feature a raptorial appendage comprising a Bouligand architecture of chitin nanofibrils with newly observed voids or defects between the polysaccharide α-chitin and ...
Sha Yin, Haoyu Chen, Ruiheng Yang, Qinghao He, Dianhao Chen, Lin Ye, Yiu-Wing Mai, Jun Xu, Robert O. Ritchie   +8 more
doaj   +1 more source

Imperfect information: information sets and sub-game perfection [Game theory]

, 2011
Educação Superior::Ciências Sociais Aplicadas::EconomiaPresents a class about imperfect information on Economics. In games, the person has consider that exist both simultaneous and sequential components, combining ideas from before and after the midterm.
Polak, Ben
core   +2 more sources

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Non-comoving cold dark matter in a $$\varLambda $$ Λ CDM background

European Physical Journal C: Particles and Fields, 2021
We examine the evolution of peculiar velocities of cold dark matter (CDM) in localized arrays of inhomogeneous cosmic structures in a $$\varLambda $$ Λ CDM background that can be identified as a frame comoving with the Cosmic Microwave (CMB).
Sebastián Nájera, Roberto A. Sussman
doaj   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Study on the effects of initial stress and imperfect interface on static and dynamic problems in thermoelastic laminated plates

Science and Engineering of Composite Materials
Based on the generalized thermoelasticity theory, the influence of initial stress and imperfect thermal interfaces on the static and dynamic problems of the simply supported thermoelastic laminated plate is investigated. Besides adopting the spring-layer
Yunying Zhou, Jiahuan Liu, Hong Mei, Dinggui Hou, Zhijie Yue, Yunxia Zhang   +5 more
doaj   +1 more source