Results 91 to 100 of about 733,404 (291)

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

Exploring Generalizable Automated Program Repair With Large Language Models

IEEE Access
Automated Program Repair (APR) proposes bug fixes to aid developers in maintaining software. The state of the art in this domain focuses on LLMs, leveraging their strong capabilities to comprehend specifications in natural language and to generate ...
Viola Campos, Ridwan Shariffdeen, Adrian Ulges, Yannic Noller   +3 more
doaj   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

ECM formation and degradation during fibrosis, repair, and regeneration

npj Metabolic Health and Disease
Imperfect attempts at organ repair after repeated injury result in aberrant formation of extracellular matrix (ECM) and loss of tissue structure. This abnormal ECM goes from being a consequence of cellular dysregulation to become the backbone of a ...
Alejandro E. Mayorca-Guiliani, Diana Julie Leeming, Kim Henriksen, Joachim Høg Mortensen, Signe Holm Nielsen, Quentin M. Anstee, Arun J. Sanyal, Morten A. Karsdal, Detlef Schuppan   +8 more
doaj   +1 more source

Leveraging Generative AI for Modelling and Optimization of Maintenance Policies in Industrial Systems

Information
This paper explores how generative AI can enhance the modelling and optimization of maintenance policies by incorporating real-time problem-solving techniques into structured maintenance frameworks.
Adolfo Crespo Márquez, Diego Pérez Oliver   +1 more
doaj   +1 more source

Mesenchymal Stem Cell Therapy for Nonmusculoskeletal Diseases: Emerging Applications

Cell Transplantation, 2009
Mesenchymal stem cells are stem/progenitor cells originated from the mesoderm and can different into multiple cell types of the musculoskeletal system.
Tom K. Kuo, Jennifer H. Ho, Oscar K. Lee M.D., PhD.   +2 more
doaj   +1 more source

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

Nonparametric estimation for accelerated life testing under imperfect repair

, 2003
This paper considers nonparametric estimation of lifetime distribution of a system subject to imperfect repair, based on data from constant stress accelerated life tests.
GIORDAN M., Giordan, Marco, DIANA, GIANCARLO   +2 more
core  

Repair-mediated duplication by capture of proximal chromosomal DNA has shaped vertebrate genome evolution.

PLoS Genetics, 2009
DNA double-strand breaks (DSBs) are a common form of cellular damage that can lead to cell death if not repaired promptly. Experimental systems have shown that DSB repair in eukaryotic cells is often imperfect and may result in the insertion of extra ...
John K Pace, Shurjo K Sen, Mark A Batzer, Cédric Feschotte   +3 more
doaj   +1 more source

A graphical method to repair-cost limit replacement policies with imperfect repair

Mathematical and Computer Modelling, 2000
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Dohi, T., Kaio, N., Osaki, S.
openaire   +2 more sources