Results 111 to 120 of about 1,990,178 (318)

Imperfect information: information sets and sub-game perfection [Game theory]

, 2014
Educação Superior::Ciências Sociais Aplicadas::EconomiaPresents a class about imperfect information on Economics. In games, the person has consider that exist both simultaneous and sequential components, combining ideas from before and after the midterm.
Polak, Ben
core  

Stochastic comparisons of maintenance policies and Bayesian imperfect repair model

, 1994
The types of repairs considered in this research are: (i) perfect repair, (ii) imperfect repair and (iii) minimal repair. When a failed unit is repaired, it is returned to the good-as-new state (perfect repair), is restored to its condition just prior to
Lim, Jae-Hak
core   +1 more source

A framework for post-prognosis decision-making utilizing deep reinforcement learning considering imperfect maintenance decisions and Value of Information

Array
The digitalization era has introduced an abundance of data that can be harnessed to monitor and predict the health of structures. This paper presents a comprehensive framework for post-prognosis decision-making that utilizes deep reinforcement learning ...
P. Komninos, D. Zarouchas
doaj   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Repairing or Embracing Human Imperfection?

MEΘEXIS Journal of Research in Values and Spirituality
The search for the fullness of human existence manifests itself in a secular society on two levels: first, the predominant claim is that the fulness of existence is within the reach of human effort, any reference to the transcendence is not necessary; second, the fullness of existence also needs to include transcendental dimensions. Modern Pelagianism,
openaire   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

Refinement of amino‐acid conformation vs. difference density maps in time‐resolved serial femtosecond crystallography data analysis

FEBS Open Bio, EarlyView.
The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong, Yuhei Hosokawa, Lars Oliver Essen, Manuel Maestre‐Reyna   +3 more
wiley   +1 more source

Imperfect information: information sets and sub-game perfection [Game theory]

, 2010
Educação Superior::Ciências Sociais Aplicadas::EconomiaPresents a class about imperfect information on Economics. In games, the person has consider that exist both simultaneous and sequential components, combining ideas from before and after the midterm.
Polak, Ben
core