Results 101 to 110 of about 100,307 (296)
FEBS Open Bio, EarlyView.Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane +11 more
wiley +1 more source
A Repair-Time Limit Replacement Model with Imperfect Repair
Journal of Korean Institute of Industrial Engineers, 2013 This article concerns a profit model in a repair limit replacement problem with imperfect repair. If a system fails, we should decide whether we repair the failed system (repair option) or replace it by new one (replacement option with a lead time).
Il Han Chung, Won Young Yun
openaire +2 more sources
Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis
FEBS Open Bio, EarlyView.Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho +4 more
wiley +1 more source
Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs
FEBS Open Bio, EarlyView.Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner +7 more
wiley +1 more source
Stem Cells International, 2018 Cutaneous wound repair is a highly coordinated cascade of cellular responses to injury which restores the epidermal integrity and its barrier functions.
Michael S. Hu +4 more
doaj +1 more source
, 2012 In the present paper we consider general counting processes stopped at a random time $T$, independent of the process. Provided that $T$ has the decreasing failure rate (DFR) property, we give sufficient conditions on the arrival times so that the number ...
Asmussen +39 more
core +1 more source
FEBS Open Bio, EarlyView.Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin +3 more
wiley +1 more source
Mathematical and Computer Modelling, 2011 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Ya-Hui Lin, Jen-Ming Chen, Yan-Chun Chen
openaire +2 more sources
Aging and Cancer, EarlyView.ABSTRACT As global populations age, cancer is increasingly becoming a leading cause of morbidity and mortality among older adults, particularly in low‐ and middle‐income countries (LMICs). Despite accounting for the majority of new cancer cases and deaths, older individuals remain underrepresented in cancer research, clinical guidelines, and health ...
Ibrahim Bidemi Abdullateef +2 more
wiley +1 more source
Cost Analysis of Series Systems with Different Standby Components and Imperfect Coverage
Operations Research and Decisions, 2019 The authors calculate the steady-state availability and the cost-benefit analysis for three different systems with mixed standby (cold standby, warm standby) and imperfect coverage.
Mohamed El-Sherbeny, Zienab M. Hussien
doaj