Results 101 to 110 of about 733,404 (291)

Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy

Molecular Oncology, EarlyView.
LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir, Elena Haro‐Martínez, Sandra Blasco‐Benito, Chiara Cannatà, José Ángel Palomeque, Anna López‐Plana, Maria Sanz‐Flores, Marc Sabartés, Cristina Fornaguera, Toni Celià‐Terrassa   +9 more
wiley   +1 more source

Parameter Estimation for a Model With Both Imperfect Test and Repair

, 2008
We describe estimation of the parameters of a manufacturing test and repair model using data available from that test. The model allows imperfect testing and imperfect repair.
Simon Wilson, Robert Kennedy, Ben Flood, Susan Bergin, Jim Mosher, Suresh Goyal   +5 more
core  

REPAIR EFFICIENCY ESTIMATION IN THE ARI1 IMPERFECT REPAIR MODEL

, 2005
The aim of this paper is to study the estimation of repair efficiency in an imperfect repair model, called Arithmetic Reduction of Intensity model with memory one (ARI1).
Laurent Doyen, Doyen, Laurent, Alyson Wilson, Nikolaos Limnios, Sallie Keller-McNulty, Yvonne Armijo   +5 more
core   +1 more source

USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival

Molecular Oncology, EarlyView.
CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna, Jodie Hay, Michael W. Moles, Lucy Clarke, Jennifer Cassels, Alison Sefcick, Alison M. McCaig, Heather G. Jørgensen, Alison M. Michie   +8 more
wiley   +1 more source

Selective maintenance for binary systems using age-based imperfect repair model

, 2012
In many applications, the break between successive missions provides an opportunity to perform maintenance under limited resources. Such maintenance policy is called selective maintenance.
Zuo, M. J, Moghaddass, R, Ming J. Zuo, Pandey, M, Mayank Pandey, Ramin Moghaddass   +5 more
core   +1 more source

A framework for post-prognosis decision-making utilizing deep reinforcement learning considering imperfect maintenance decisions and Value of Information

Array
The digitalization era has introduced an abundance of data that can be harnessed to monitor and predict the health of structures. This paper presents a comprehensive framework for post-prognosis decision-making that utilizes deep reinforcement learning ...
P. Komninos, D. Zarouchas
doaj   +1 more source

Small RNA pathways in mammalian oocytes

FEBS Open Bio, EarlyView.
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Endonuclease V-Mediated Deoxyinosine Excision Repair in Vitro

, 2011
Deoxyinosine (dI) in DNA can arise from hydrolytic or nitrosative deamination of deoxyadenosine It is excised in a -repair pathway that is initiated by endonuclease V.
楊雅倩;林淑萍;高照村;蔡克嵩;方偉宏, YANG, YA-CHIEN;STEVEN, D. GOODMAN;LIN, SHWU-BIN;KAO, JAU-TSUEN;TSAI, KEH-SUNG;FANG, WOEI-HORNG   +1 more
core   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source