Results 81 to 90 of about 100,307 (296)

A discounted model for a repairable system with continuous state space [PDF]

, 2000
We examine repairable systems with a continous state space and partial repair options, carried out at fixed times $n=1,2,...$. Every time interval $[n,n+1)$ there is a manufacturing cost and a repair cost.
Bruns, P.B.
core   +2 more sources

Supporting Attention Allocation in Multitask Environments : Effects of Likelihood Alarm Systems on Trust, Behavior, and Performance [PDF]

, 2014
Dieser Beitrag ist mit Zustimmung des Rechteinhabers aufgrund einer (DFG geförderten) Allianz- bzw. Nationallizenz frei zugänglich.This publication is with permission of the rights owner freely accessible due to an Alliance licence and a national licence
Manzey, Dietrich, Wiczorek, Rebecca
core   +1 more source

Insights into a long life without cancer: The case of the bowhead whale

Molecular Oncology, EarlyView.
Long‐lived, large‐bodied organisms have evolved powerful anticancer mechanisms that preserve cellular and tissue integrity across extended lifespans. A recent study by Firsanov et al. shows that greater genome stability is a key factor underlying the remarkable longevity and cancer resistance of one such species, the bowhead whale.
Inés Paniagua, Johanna A. Joyce
wiley   +1 more source

DNA repair and the contribution to chemotherapy resistance

Genome Medicine
The DNA damage response comprises a set of imperfect pathways that maintain cell survival following exposure to DNA damaging agents. Cancers frequently exhibit DNA repair pathway alterations that contribute to their intrinsic genome instability. This, in
Ksenija Nesic, Phoebe Parker, Elizabeth M. Swisher, John J. Krais   +3 more
doaj   +1 more source

Salvaging External Iliac Artery Dissection during Renal Transplant: A Case Series

Indian Journal of Transplantation
External iliac artery dissection is a rare and reversible but serious complication of renal transplant that may ultimately lead to loss of kidney and lower limb.
Neethu Varghese, Benil Hafeeq, Jyotish Chalil Gopinathan   +2 more
doaj   +1 more source

AAV-Mediated CRISPR/Cas9 Gene Editing in Murine Phenylketonuria

Molecular Therapy: Methods & Clinical Development, 2020
Phenylketonuria (PKU) due to recessively inherited phenylalanine hydroxylase (PAH) deficiency results in hyperphenylalaninemia, which is toxic to the central nervous system. Restriction of dietary phenylalanine intake remains the standard of PKU care and
Daelyn Y. Richards, Shelley R. Winn, Sandra Dudley, Sean Nygaard, Taylor L. Mighell, Markus Grompe, Cary O. Harding   +6 more
doaj   +1 more source

“I Understood You, But There was This Pronunciation Thing…”: L2 Pronunciation Feedback in English/French Tandem Interactions [PDF]

, 2013
We hope that our data brings a valuable and fairly unique contribution to SLA research, helping to establish which errors get corrected and how it may have implications for setting priorities in L2 pronunciation ...
Brammerts, Brammerts, Brammerts, Brammerts, Céline Horgues, Doughty, Doughty, Ellis, Ellis, Ellis, Ellis, Gass, Gass, Horgues, Horgues, James, James, Jenkins, Jenkins, Kramsch, Kramsch, Lyster, Lyster, Lyster, Lyster, Mackey, Mackey, Mackey, Mackey, Markham, Markham, Ritchie, Ritchie, Rourke, Rourke, Sato, Sato, Schmidt, Schmidt, Sheen, Sheen, Sylwia Scheuer, Tatawy, Tatawy   +43 more
core   +5 more sources

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Circulating tumor cell viability during and after radiotherapy mirrors treatment response in cancer patients

Molecular Oncology, EarlyView.
Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy, Jana Löptien, Cornelia Coith, Afroditi Nanou, Katharina Hintelmann, Pinnschmidt Hans, Cordula Petersen, Klaus Pantel, Sabine Riethdorf, Kerstin Borgmann, Harriet Wikman   +10 more
wiley   +1 more source

Emerging Pronoun Practices After the Procedural Turn: Disclosure, Discovery, and Repair

Sociological Science
We examine emerging practices of pronoun disclosure, discovery, and repair after the procedural turn in pronoun politics, which shifted attention from the substantive question of which pronouns should be used to the procedural question of how preferred ...
Julieta Goldenberg, Rogers Brubaker
doaj   +1 more source