Results 61 to 70 of about 733,404 (291)

Prospecting the protein design landscape

FEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona, Katharina T. Stonig, Jens Meiler, Clara T. Schoeder, Monica L. Fernández‐Quintero   +4 more
wiley   +1 more source

Anomalous two-step repair mechanism of Al–Cu alloy regulated by the surroundings during E-beam irradiation

Journal of Materials Research and Technology
Understanding the repair mechanisms of defects is essential for gaining insight into improving the quality and enhancing the performance of materials.
Weiwei Xia, Yu Wang, Quan An, Lianyang Chen, Ran Cai   +4 more
doaj   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Decline and repair, and covariate effects [PDF]

, 2015
The failure processes of repairable systems may be impacted by operational and environmental stress factors. To accommodate such factors, reliability can be modelled using a multiplicative intensity function.
Scarf, PA, Scarf, Philip, Wu, Shaomin
core   +1 more source

DNA repair and the contribution to chemotherapy resistance

Genome Medicine
The DNA damage response comprises a set of imperfect pathways that maintain cell survival following exposure to DNA damaging agents. Cancers frequently exhibit DNA repair pathway alterations that contribute to their intrinsic genome instability. This, in
Ksenija Nesic, Phoebe Parker, Elizabeth M. Swisher, John J. Krais   +3 more
doaj   +1 more source

Salvaging External Iliac Artery Dissection during Renal Transplant: A Case Series

Indian Journal of Transplantation
External iliac artery dissection is a rare and reversible but serious complication of renal transplant that may ultimately lead to loss of kidney and lower limb.
Neethu Varghese, Benil Hafeeq, Jyotish Chalil Gopinathan   +2 more
doaj   +1 more source

Beyond repair foci: DNA double-strand break repair in euchromatic and heterochromatic compartments analyzed by transmission electron microscopy. [PDF]

PLoS ONE, 2012
DNA double-strand breaks (DSBs) generated by ionizing radiation pose a serious threat to the preservation of genetic and epigenetic information. The known importance of local chromatin configuration in DSB repair raises the question of whether breaks in ...
Yvonne Lorat, Stefanie Schanz, Nadine Schuler, Gunther Wennemuth, Christian Rübe, Claudia E Rübe   +5 more
doaj   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

The Lorenz Transform approach to the Optimal Repair-Cost limit remplacement Policy with Imperfect Repair

, 2002
In this paper, we consider a repair-cost limit replacement problem with imperfect repair and develop a graphical method to determine the optimal repair-cost limit which minimizes the expected cost per unit time in the steady-state, using the Lorenz ...
Sunji Osaki, N. Kaio, F. S. Othman, T. Dohi   +3 more
core   +1 more source

Inhibition of dipeptidyl peptidase 7 impairs lysophagy in LLOMe‐treated HepG2 cells

FEBS Letters, EarlyView.
DPP7 inhibition delays ubiquitin‐dependent lysophagy by attenuating ubiquitin accumulation and the recruitment of SQSTM1 and LC3 to damaged lysosomes, resulting in delayed clearance of damaged lysosomes and impaired restoration of lysosomal homeostasis. Created using FigureLabs (Certificate ID: FL‐PUB‐20260922‐Z99XNX).
Na Yeon Park, Inho Kwon, Yong Hwan Kim, Ji‐Eun Bae, Joon Bum Kim, Seong Hyun Kim, Sungho Maeng, Doo Sin Jo, Dong‐Hyung Cho   +8 more
wiley   +1 more source