Results 51 to 60 of about 1,990,178 (318)
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
机车电传动, 2022 Considering that the entire electric multiple unit (EMU) needs to be withdrawn from service for carrying out preventive maintenance (PM) of the critical equipment, leading to an increase to downtime loss, the concept of replacement repair is proposed in ...
XIONG Lü, LIU Zhilong
doaj
How Does the Chinese Government Promote the Development of the Social Credit System?
Управленческое консультирование, 2022 This paper introduces the four stages of the construction of China’s social credit system. In combination with the characteristics of the institutional system, this paper describes the specific practices adopted by the Chinese government to promote the ...
Yong Zhong
doaj +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Short-term Power System Maintenance Scheduling with Imperfect Repair
IOP Conference Series: Materials Science and Engineering, 2019 Most of the existing research in short-term power system maintenance scheduling assumes that repair is minimal when equipment fails. However, this may not always be the truth because sometimes repair after failure is imperfect.
Bo Xu, Shenzhi Xu, Yumin Zhang
semanticscholar +1 more source
Imperfect Preventive Maintenance Model Study Based On Reliability Limitation
MATEC Web of Conferences, 2016 Effective maintenance is crucial for equipment performance in industry. Imperfect maintenance conform to actual failure process. Taking the dynamic preventive maintenance cost into account, the preventive maintenance model was constructed by using age ...
Zhou Qian, Sun Yufeng
doaj +1 more source
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
Endonuclease V-Mediated Deoxyinosine Excision Repair in Vitro
, 2011 Deoxyinosine (dI) in DNA can arise from hydrolytic or nitrosative deamination of deoxyadenosine It is excised in a -repair pathway that is initiated by endonuclease V.
楊雅倩;林淑萍;高照村;蔡克嵩;方偉宏 +1 more
core +1 more source
Reliability and Availability Analysis of a Two-Unit Cold Standby System with Imperfect Switching
AxiomsThis paper presents a stochastic analysis of a two-unit cold standby system incorporating imperfect switching mechanisms. Each unit operates in one of three states: normal, partial failure, or total failure.
Nariman M. Ragheb +3 more
doaj +1 more source
Journal of Engineering, 2016 The interfaces between the deposition products and concrete are not always well bonded when the electrochemical deposition method (EDM) is adopted to repair the deteriorated concrete.
Qing Chen +5 more
doaj +1 more source