Results 51 to 60 of about 733,404 (291)

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Imperfect Preventive Maintenance Model Study Based On Reliability Limitation

MATEC Web of Conferences, 2016
Effective maintenance is crucial for equipment performance in industry. Imperfect maintenance conform to actual failure process. Taking the dynamic preventive maintenance cost into account, the preventive maintenance model was constructed by using age ...
Zhou Qian, Sun Yufeng
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

An Improved Micromechanical Framework for Saturated Concrete Repaired by the Electrochemical Deposition Method considering the Imperfect Bonding

Journal of Engineering, 2016
The interfaces between the deposition products and concrete are not always well bonded when the electrochemical deposition method (EDM) is adopted to repair the deteriorated concrete.
Qing Chen, Zhengwu Jiang, Hehua Zhu, J. Woody Ju, Zhiguo Yan, Yaqiong Wang   +5 more
doaj   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Reliability and Availability Analysis of a Two-Unit Cold Standby System with Imperfect Switching

Axioms
This paper presents a stochastic analysis of a two-unit cold standby system incorporating imperfect switching mechanisms. Each unit operates in one of three states: normal, partial failure, or total failure.
Nariman M. Ragheb, Emad Solouma, Abdullah A. Alahmari, Sayed Saber   +3 more
doaj   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Research on imperfect condition-based maintenance strategy based on accelerated degradation process

Measurement + Control
To address the situation that the degraded system cannot be repaired as new and the degradation is accelerated after repair in engineering practice, an imperfect condition-based maintenance model is proposed based on the Gamma process by introducing the ...
Jintao Chen, Lina Ren, Jianhua Li
doaj   +1 more source

Preventive maintenance policy on leasing by considering the usage rate

MATEC Web of Conferences, 2018
The needs of the consumers about the functionality of a product and increase maintenance costs of equipment caused the prices of products and treatments to be expensive. Therefore, the company considers the lease rather than buy it.
Jufriyanto Moh., Kurniati Nani, Supriatna Ade   +2 more
doaj   +1 more source

An estimate of maintenance efficiency in Brown-Proschan imperfect repair model with bathtub failure intensity

Journal of Industrial Engineering and Management, 2012
Purpose: Estimate the maintenance efficiency in the Brown-Proschan model with the bathtub failure intensity.Design/methodology/approach: Empirical research through which we propose a framework to establish the characteristics of failure process and its ...
Makram Krit, Abdelwaheb Rebai
doaj   +1 more source