Results 51 to 60 of about 15,461 (258)

Research on imperfect condition-based maintenance strategy based on accelerated degradation process

Measurement + Control
To address the situation that the degraded system cannot be repaired as new and the degradation is accelerated after repair in engineering practice, an imperfect condition-based maintenance model is proposed based on the Gamma process by introducing the ...
Jintao Chen, Lina Ren, Jianhua Li
doaj   +1 more source

Beyond repair foci: DNA double-strand break repair in euchromatic and heterochromatic compartments analyzed by transmission electron microscopy. [PDF]

PLoS ONE, 2012
DNA double-strand breaks (DSBs) generated by ionizing radiation pose a serious threat to the preservation of genetic and epigenetic information. The known importance of local chromatin configuration in DSB repair raises the question of whether breaks in ...
Yvonne Lorat, Stefanie Schanz, Nadine Schuler, Gunther Wennemuth, Christian Rübe, Claudia E Rübe   +5 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Salvaging External Iliac Artery Dissection during Renal Transplant: A Case Series

Indian Journal of Transplantation
External iliac artery dissection is a rare and reversible but serious complication of renal transplant that may ultimately lead to loss of kidney and lower limb.
Neethu Varghese, Benil Hafeeq, Jyotish Chalil Gopinathan   +2 more
doaj   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

DNA repair and the contribution to chemotherapy resistance

Genome Medicine
The DNA damage response comprises a set of imperfect pathways that maintain cell survival following exposure to DNA damaging agents. Cancers frequently exhibit DNA repair pathway alterations that contribute to their intrinsic genome instability. This, in
Ksenija Nesic, Phoebe Parker, Elizabeth M. Swisher, John J. Krais   +3 more
doaj   +1 more source

Anomalous two-step repair mechanism of Al–Cu alloy regulated by the surroundings during E-beam irradiation

Journal of Materials Research and Technology
Understanding the repair mechanisms of defects is essential for gaining insight into improving the quality and enhancing the performance of materials.
Weiwei Xia, Yu Wang, Quan An, Lianyang Chen, Ran Cai   +4 more
doaj   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Circulating tumor cell viability during and after radiotherapy mirrors treatment response in cancer patients

Molecular Oncology, EarlyView.
Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy, Jana Löptien, Cornelia Coith, Afroditi Nanou, Katharina Hintelmann, Pinnschmidt Hans, Cordula Petersen, Klaus Pantel, Sabine Riethdorf, Kerstin Borgmann, Harriet Wikman   +10 more
wiley   +1 more source

Parameter Estimation for a Model with Both Imperfect Test and Repair [PDF]

25th IEEE VLSI Test Symmposium (VTS'07), 2007
We describe estimation of the parameters of a manufacturing test and repair model using data available from that test. The model allows imperfect testing and imperfect repair. The principal problem that we address is of parameter identification, given insufficient data, that we address by making conservative assumptions on the property being measured ...
Simon P. Wilson 0001, Ben Flood, Suresh Goyal, Jim Mosher, Susan Bergin, Joseph O'Brien, Robert Kennedy   +6 more
openaire   +3 more sources