Results 41 to 50 of about 15,461 (258)

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Imperfect Preventive Maintenance Model Study Based On Reliability Limitation

MATEC Web of Conferences, 2016
Effective maintenance is crucial for equipment performance in industry. Imperfect maintenance conform to actual failure process. Taking the dynamic preventive maintenance cost into account, the preventive maintenance model was constructed by using age ...
Zhou Qian, Sun Yufeng
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

An Improved Micromechanical Framework for Saturated Concrete Repaired by the Electrochemical Deposition Method considering the Imperfect Bonding

Journal of Engineering, 2016
The interfaces between the deposition products and concrete are not always well bonded when the electrochemical deposition method (EDM) is adopted to repair the deteriorated concrete.
Qing Chen, Zhengwu Jiang, Hehua Zhu, J. Woody Ju, Zhiguo Yan, Yaqiong Wang   +5 more
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Reliability and Availability Analysis of a Two-Unit Cold Standby System with Imperfect Switching

Axioms
This paper presents a stochastic analysis of a two-unit cold standby system incorporating imperfect switching mechanisms. Each unit operates in one of three states: normal, partial failure, or total failure.
Nariman M. Ragheb, Emad Solouma, Abdullah A. Alahmari, Sayed Saber   +3 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Preventive maintenance policy on leasing by considering the usage rate

MATEC Web of Conferences, 2018
The needs of the consumers about the functionality of a product and increase maintenance costs of equipment caused the prices of products and treatments to be expensive. Therefore, the company considers the lease rather than buy it.
Jufriyanto Moh., Kurniati Nani, Supriatna Ade   +2 more
doaj   +1 more source

An estimate of maintenance efficiency in Brown-Proschan imperfect repair model with bathtub failure intensity

Journal of Industrial Engineering and Management, 2012
Purpose: Estimate the maintenance efficiency in the Brown-Proschan model with the bathtub failure intensity.Design/methodology/approach: Empirical research through which we propose a framework to establish the characteristics of failure process and its ...
Makram Krit, Abdelwaheb Rebai
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source