Results 31 to 40 of about 99,909 (304)
Parallel analysis of ribonucleotide-dependent deletions produced by yeast Top1 in vitro and in vivo [PDF]
, 2016 Ribonucleotides are the most abundant non-canonical component of yeast genomic DNA and their persistence is associated with a distinctive mutation signature characterized by deletion of a single repeat unit from a short tandem repeat.
Burgers, Peter M +5 more
core +2 more sources
Yeast pol4 promotes tel1-regulated chromosomal translocations. [PDF]
PLoS Genetics, 2013 DNA double-strand breaks (DSBs) are one of the most dangerous DNA lesions, since their erroneous repair by nonhomologous end-joining (NHEJ) can generate harmful chromosomal rearrangements.
Jose F Ruiz +4 more
doaj +1 more source
System Maintenance Using Several Imperfect Repairs Before a Perfect Repair
Statistics, Optimization & Information Computing, 2021 Allowing several imperfect repairs before a perfect repair can lead to a highly reliable and efficient system by reducing repair time and repair cost. Assuming exponential lifetime and exponential repair time, we determine the optimal probability $p$ of choosing a perfect repair over an imperfect repair after each failure.
Smithson, Haixia, Sarkar, Jyotirmoy
openaire +2 more sources
Reconstruction of a long defect of the median nerve with a free nerve conduit flap
Archives of Plastic Surgery, 2020 Upper limb nerve damage is a common condition, and evidence suggests that functional recovery may be limited following peripheral nerve repair in cases of delayed reconstruction or reconstruction of long nerve defects.
Andrea Campodonico +3 more
doaj +1 more source
Is non-homologous end-joining really an inherently error-prone process? [PDF]
PLoS Genetics, 2014 DNA double-strand breaks (DSBs) are harmful lesions leading to genomic instability or diversity. Non-homologous end-joining (NHEJ) is a prominent DSB repair pathway, which has long been considered to be error-prone.
Mireille Bétermier +2 more
doaj +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Although most malignant germ cell tumors (GCTs) are highly curable with cisplatin‐based therapy, options for patients with multiply relapsed/refractory disease remain limited. For this population, we report the first pediatric use of gemcitabine, docetaxel, melphalan, and carboplatin (GemDMC) as part of sequential cycles of high‐dose ...
Maria Frost +10 more
wiley +1 more source
How Does the Chinese Government Promote the Development of the Social Credit System?
Управленческое консультирование, 2022 This paper introduces the four stages of the construction of China’s social credit system. In combination with the characteristics of the institutional system, this paper describes the specific practices adopted by the Chinese government to promote the ...
Yong Zhong
doaj +1 more source
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source