Results 51 to 60 of about 99,909 (304)
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Journal of Engineering, 2016 The interfaces between the deposition products and concrete are not always well bonded when the electrochemical deposition method (EDM) is adopted to repair the deteriorated concrete.
Qing Chen +5 more
doaj +1 more source
The Importance of DNA Repair in Tumor Suppression
, 2004 The transition from a normal to cancerous cell requires a number of highly specific mutations that affect cell cycle regulation, apoptosis, differentiation, and many other cell functions.
B. Vogelstein +8 more
core +1 more source
A Repair-Time Limit Replacement Model with Imperfect Repair
Journal of Korean Institute of Industrial Engineers, 2013 This article concerns a profit model in a repair limit replacement problem with imperfect repair. If a system fails, we should decide whether we repair the failed system (repair option) or replace it by new one (replacement option with a lead time).
Il Han Chung, Won Young Yun
openaire +2 more sources
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Reliability and Availability Analysis of a Two-Unit Cold Standby System with Imperfect Switching
AxiomsThis paper presents a stochastic analysis of a two-unit cold standby system incorporating imperfect switching mechanisms. Each unit operates in one of three states: normal, partial failure, or total failure.
Nariman M. Ragheb +3 more
doaj +1 more source
Journal of Industrial Engineering and Management, 2012 Purpose: Estimate the maintenance efficiency in the Brown-Proschan model with the bathtub failure intensity.Design/methodology/approach: Empirical research through which we propose a framework to establish the characteristics of failure process and its ...
Makram Krit, Abdelwaheb Rebai
doaj +1 more source
Economic order quantity model of imperfect items using single sampling plan for attributes
Journal of Applied Science and Engineering, 2022 In this paper, an economic order quantity (EOQ) model is proposed for imperfect items in a lot of products. A single sampling plan is considered in this model. The sample in a lot of products is chosen and inspected by attribute.
Panuwat Pimsap, Wuttichai Srisodaphol
doaj +1 more source
Molecular Oncology, EarlyView.This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns +10 more
wiley +1 more source
Preventive maintenance policy on leasing by considering the usage rate
MATEC Web of Conferences, 2018 The needs of the consumers about the functionality of a product and increase maintenance costs of equipment caused the prices of products and treatments to be expensive. Therefore, the company considers the lease rather than buy it.
Jufriyanto Moh. +2 more
doaj +1 more source