Results 61 to 70 of about 99,909 (304)

Beyond repair foci: DNA double-strand break repair in euchromatic and heterochromatic compartments analyzed by transmission electron microscopy. [PDF]

PLoS ONE, 2012
DNA double-strand breaks (DSBs) generated by ionizing radiation pose a serious threat to the preservation of genetic and epigenetic information. The known importance of local chromatin configuration in DSB repair raises the question of whether breaks in ...
Yvonne Lorat, Stefanie Schanz, Nadine Schuler, Gunther Wennemuth, Christian Rübe, Claudia E Rübe   +5 more
doaj   +1 more source

A discounted model for a repairable system with continuous state space [PDF]

, 2000
We examine repairable systems with a continous state space and partial repair options, carried out at fixed times $n=1,2,...$. Every time interval $[n,n+1)$ there is a manufacturing cost and a repair cost.
Bruns, P.B.
core   +2 more sources

Supporting Attention Allocation in Multitask Environments : Effects of Likelihood Alarm Systems on Trust, Behavior, and Performance [PDF]

, 2014
Dieser Beitrag ist mit Zustimmung des Rechteinhabers aufgrund einer (DFG geförderten) Allianz- bzw. Nationallizenz frei zugänglich.This publication is with permission of the rights owner freely accessible due to an Alliance licence and a national licence
Manzey, Dietrich, Wiczorek, Rebecca
core   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Research on imperfect condition-based maintenance strategy based on accelerated degradation process

Measurement + Control
To address the situation that the degraded system cannot be repaired as new and the degradation is accelerated after repair in engineering practice, an imperfect condition-based maintenance model is proposed based on the Gamma process by introducing the ...
Jintao Chen, Lina Ren, Jianhua Li
doaj   +1 more source

“I Understood You, But There was This Pronunciation Thing…”: L2 Pronunciation Feedback in English/French Tandem Interactions [PDF]

, 2013
We hope that our data brings a valuable and fairly unique contribution to SLA research, helping to establish which errors get corrected and how it may have implications for setting priorities in L2 pronunciation ...
Brammerts, Brammerts, Brammerts, Brammerts, Céline Horgues, Doughty, Doughty, Ellis, Ellis, Ellis, Ellis, Gass, Gass, Horgues, Horgues, James, James, Jenkins, Jenkins, Kramsch, Kramsch, Lyster, Lyster, Lyster, Lyster, Mackey, Mackey, Mackey, Mackey, Markham, Markham, Ritchie, Ritchie, Rourke, Rourke, Sato, Sato, Schmidt, Schmidt, Sheen, Sheen, Sylwia Scheuer, Tatawy, Tatawy   +43 more
core   +5 more sources

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Anomalous two-step repair mechanism of Al–Cu alloy regulated by the surroundings during E-beam irradiation

Journal of Materials Research and Technology
Understanding the repair mechanisms of defects is essential for gaining insight into improving the quality and enhancing the performance of materials.
Weiwei Xia, Yu Wang, Quan An, Lianyang Chen, Ran Cai   +4 more
doaj   +1 more source

Exact two-terminal reliability of some directed networks

, 2007
The calculation of network reliability in a probabilistic context has long been an issue of practical and academic importance. Conventional approaches (determination of bounds, sums of disjoint products algorithms, Monte Carlo evaluations, studies of the
Tanguy, Christian
core   +3 more sources

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source