A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source
Are the Outcomes of Immediate and Early Single Tooth Implants Comparable to Conventionally Placed Implants? [PDF]
, 2009 Data Sources Medline, Embase, the Cochrane Central Register of Controlled Trials (Central) and references of relevant studies were searched. Study selection Longitudinal studies [randomised controlled trials (RCT), clinical trials, cohort-studies and ...
Stafford, Gary L
core +1 more source
Molecular Oncology, EarlyView.Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié +16 more
wiley +1 more source
Effect of pore size on bone ingrowth into porous titanium implants fabricated by additive manufacturing: An in vivo experiment [PDF]
, 2015 Naoya Taniguchi +8 more
openalex +1 more source
Transcatheter Mitral Valve Implantation: Current Status and Future Perspectives [PDF]
, 2021 Giulio Russo +6 more
openalex +1 more source
Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Genetic testing in epithelial ovarian cancer includes both germline and tumor‐testing. This approach often duplicates resources. The current prospective study assessed the feasibility of tumor‐first multigene testing by comparing tumor tissue with germline testing of peripheral blood using an 18‐gene NGS panel in 106 patients.
Elisabeth Spenard +12 more
wiley +1 more source
Current Directions in Biomedical Engineering, 2019 Although the development of the transcatheter aortic valve (TAV) has saved many lives of inoperable patients and has a very good clinical outcome, concerns about valve thrombosis are increasing.
Stiehm Michael +8 more
doaj +1 more source
A nomogram to determine required seed air kerma strength in planar 131 Cesium permanent seed implant brachytherapy [PDF]
, 2019 Purpose: Intraoperatively implanted Cesium-131 ( 131 Cs) permanent seed brachytherapy is used to deliver highly localized re-irradiation in recurrent head and neck cancers.
Bar-Ad, Voichita +4 more
core +1 more source
Implantation and explantation of an active epiretinal visual prosthesis: 2-year follow-up data from the EPIRET3 prospective clinical trial [PDF]
, 2012 Johannes Menzel-Severing +7 more
openalex +1 more source