Results 71 to 80 of about 677,246 (299)

Implant Fibrosis and the Underappreciated Role of Myofibroblasts in the Foreign Body Reaction [PDF]

, 2021
Nina Noskovičová, Boris Hinz, Pardis Pakshir   +2 more
openalex   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

2021 PACES expert consensus statement on the indications and management of cardiovascular implantable electronic devices in pediatric patients [PDF]

, 2021
Maully J. Shah, Michael J. Silka, Jennifer N. Avari Silva, Seshadri Balaji, Cheyenne M. Beach, Monica N. Benjamin, Charles I. Berul, Bryan C. Cannon, Frank Cecchin, Mitchell I. Cohen, Aarti Dalal, Brynn E. Dechert, Anne Foster, Roman Gebauer, M. Cecilia Gonzalez Corcia, Prince J. Kannankeril, Peter P. Karpawich, Jeffery J. Kim, Mani Ram Krishna, Peter Kubuš, Martin J. LaPage, Douglas Y. Mah, Lindsey Malloy-Walton, Aya Miyazaki, Kara S. Motonaga, Mary C. Niu, Melissa Olen, Thomas Paul, Éric Rosenthal, Elizabeth V. Saarel, Massimo Stefano Silvetti, Elizabeth A. Stephenson, Reina Bianca Tan, John K. Triedman, Nicholas H. Von Bergen, Philip L. Wackel, Document Reviewers: Philip M. Chang, Fabrizio Drago, Anne M. Dubin, Susan P. Etheridge, Apichai Kongpatanayothin, Jose Manuel Moltedo, Ashish A. Nabar and George F. Van Hare   +36 more
openalex   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Improved control of a prosthetic limb by surgically creating electro-neuromuscular constructs with implanted electrodes [PDF]

, 2023
Jan Zbinden, Paolo Sassu, Enzo Mastinu, Eric J. Earley, Maria Munoz-Novoa, Rickard Brånemark, Max Ortiz-Catalan   +6 more
openalex   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Computational flow analysis of the washout of an aortic valve by means of Eulerian transport equation

Current Directions in Biomedical Engineering, 2019
Although the development of the transcatheter aortic valve (TAV) has saved many lives of inoperable patients and has a very good clinical outcome, concerns about valve thrombosis are increasing.
Stiehm Michael, Borowski Finja, Kaule Sebastian, Ott Robert, Pfensig Sylvia, Siewert Stefan, Schmitz Klaus-Peter, Öner Alper Ö, Grabow Niels   +8 more
doaj   +1 more source

ADAMTS-1: a novel target gene of an estrogen-induced transcription factor, EGR1, critical for embryo implantation in the mouse uterus [PDF]

, 2021
Mira Park, Sohee Park, Hyunsun Park, Hye Ryun Kim, Hyunjung Jade Lim, Haengseok Song   +5 more
openalex   +1 more source

Tumor and germline testing with next generation sequencing in epithelial ovarian cancer: a prospective paired comparison using an 18‐gene panel

Molecular Oncology, EarlyView.
Genetic testing in epithelial ovarian cancer includes both germline and tumor‐testing. This approach often duplicates resources. The current prospective study assessed the feasibility of tumor‐first multigene testing by comparing tumor tissue with germline testing of peripheral blood using an 18‐gene NGS panel in 106 patients.
Elisabeth Spenard, Cristina Mitric, Melanie Care, Tracy L. Stockley, Raymond H. Kim, Jeanna McCuaig, Blaise Clarke, Laura Ranich, Clare Sheen, Sarah E. Ferguson, Liat Hogen, Taymaa May, Marcus Q. Bernardini   +12 more
wiley   +1 more source

AI-Driven CBCT Analysis for Surgical Decision-Making and Mucosal Damage Prediction in Sinus Lift Surgery for patients with low RBH

International Dental Journal
Background: Decision-making for maxillary sinus floor elevation (MSFE) surgery in patients with low residual bone height (
Yinxin Deng, Yilin He, Changying Liu, Zhenhua Gao, Shujia Yu, Shiyu Cao, Chenrui Li, Qian Zhu, Pan Ma   +8 more
doaj   +1 more source