Results 71 to 80 of about 120,396 (306)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Removal of failed dental implants revisited: Questions and answers

Clinical and Experimental Dental Research, 2019
Objectives This narrative review is aiming on showing reasons for implant failure, removal techniques, and respective clinical considerations; further, the survival rate of implants in previous failed sites is examined.
Alex Solderer, Adrian Al‐Jazrawi, Philipp Sahrmann, Ronald Jung, Thomas Attin, Patrick R. Schmidlin   +5 more
doaj   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Fatigue Reliability of 3 Single-Unit Implant-Abutment Designs

, 2012
Objectives: Because the mechanical behavior of the implant-abutment system is critical for the longevity of implant-supported reconstructions, this study evaluated the fatigue reliability of different implant-abutment systems used as single-unit crowns ...
Coelho, Paulo G., Marotta, Leonard, Freitas, Amilcar C., Jr., Silva, Nelson R. F. A., Martins, Leandro M., Zavanelli, Ricardo A., Bonfante, Estevam A.   +6 more
core   +1 more source

Implantation Failure

, 2017
The purpose of this paper is to show the usefulness of an alternative scientific argument based on Transcurssive Logic in the natural science, such as medicine. The auxiliary methodology was applied to determine the role of a polyvalent endometrial treatment in patients suffering from ‘repeated implantation failure’ in an ovodonation program. Secondly,
Tersoglio, A. E., Salatino, D.R.
openaire   +2 more sources

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Implant failures and age at the time of surgery: A retrospective study on implant treatment in 2915 partially edentulous jaws

, 2019
Purpose: To further report and analyze data on the prevalence of implant failures related to age at surgery in partially edentulous jaws. Materials and Methods: Altogether, 2915 partially edentulous jaws (Kennedy Class I and II) were consecutively ...
Jemt, Torsten,, Torsten Jemt
core   +1 more source

Analysis of technical complications and risk factors for failure of combined tooth-implant-supported fixed dental prostheses

, 2020
BACKGROUND: The oral rehabilitation with fixed restorations supported by the combination of teeth and dental implants has been advocated in some cases. PURPOSE: To assess the clinical outcomes of these prostheses.
Bruno Ramos Chrcanovic, Chrcanovic, Bruno Ramos, Kisch, Jenö, Christel Larsson, Jenö Kisch, Kisch, Jenö,, Larsson, Christel,, Larsson, Christel, Chrcanovic, Bruno Ramos,   +8 more
core   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Implications of considering peri‐implant bone loss a disease, a narrative review

, 2022
BACKGROUND: Peri‐implantitis has been suggested to cause significant increasing proportions of implant failure with increasing time. PURPOSE: To assess whether implant failure rates in long term studies are matching the supposed high prevalence of peri ...
Amengual‐Peñafiel, Luis, Coli, Pierluigi,, Tengvall, Pentti, Tengvall, Pentti,, Amengual-Penafiel, L., Coli, Pierluigi, Pierluigi Coli, Georgios Kotsakis, Kotsakis, Georgios,, Cochran, D. L., Luis Amengual‐Peñafiel, Cochran, David L., Albrektsson, Tomas, Kotsakis, Georgios, David L. Cochran, Albrektsson, Tomas,, Tomas Albrektsson, Pentti Tengvall   +17 more
core   +1 more source