Results 81 to 90 of about 120,396 (306)

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

The Risk Factors in Early Failure of Dental Implants: a Retrospective Study

Journal of Dentistry, 2017
Statement of the Problem: Despite the low failure rate of dental implants, recognition of the risk factors can enhance the predictability of failure. Purpose: The aim of this study was to evaluate the risk factors for early implant failure.
Hassan Mohajerani , Roozbeh Roozbayani , Shahram Taherian , Reza Tabrizi   +3 more
doaj  

Molecular aspects of implantation failure

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2012
Despite expanding global experience with advanced reproductive technologies, the majority of IVF attempts do not result in a successful pregnancy, foremost as a result of implantation failure. The process of embryo implantation, a remarkably dynamic and precisely controlled molecular and cellular event, appears inefficient in humans and is poorly ...
Koot, Y.E.M., Teklenburg, G., Salker, M.S., Brosens, J.J., Macklon, N.S.   +4 more
openaire   +3 more sources

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Prevalência das doenças periimplantares mucosite e periimplantite . Análise de fatores de risco locais e sistêmicos. Estudo retrospectivo de 1 a 9 anos [PDF]

, 2012
Tese (doutorado) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde, Programa de Pós-Graduação em Odontologia, Florianópolis, 2012Objetivo : Determinar a prevalência de doenças periimplantares; mucosite e periimplantite, nos pacientes ...
Buttendorf, André Ricardo
core  

Clinical consequences early implant failures of IL-1 genotype on early implant failures in patients under periodontal maintenance

, 2005
Background: Implant failure and biologic complications such as periimplantitis are not completely avoidable. Are there any genetic and microbiologic parameters that Could be used to identify patients at risk for implant failure, preferably prior to ...
De Bruyn, HugoGE36UZGent0000705496158010018893350000-0003-0200-9546F73EAFBC-F0ED-11E1-A9DE-61C894A0A6B4, De Bruyn, Hugo, Hamberg, Kristina,, Bratthall, Gunilla, de Bruyn, Hugo,, Bratthall, Gunilla,, Jansson, Henrik, Hamberg, Kristina, Jansson, Henrik,   +8 more
core   +1 more source

A Study of the Associated Risk Factors for Early Failure and the Effect of Photofunctionalisation in Full-Arch Immediate Loading Treatment Based on the All-on-Four Concept

Bioengineering
Early implant failure occurring within 1 year after implantation has been attributed to various factors. Particularly, early failure can lead to challenges in maintaining a full-arch prosthetic device, necessitating prompt intervention, including ...
Takashi Uesugi, Yoshiaki Shimoo, Motohiro Munakata, Yu Kataoka, Daisuke Sato, Kikue Yamaguchi, Minoru Sanda, Michiya Fujimaki, Kazuhisa Nakayama, Tae Watanabe, Paulo Malo   +10 more
doaj   +1 more source

Clinical Management of Implant Prostheses in Patients with Bruxism

International Journal of Biomaterials, 2012
There is general agreement that excessive stress to the bone-implant interface may result in implant overload and failure. Early failure of the implant due to excessive loading occurs shortly after uncovering the implant.
Osamu Komiyama, Frank Lobbezoo, Antoon De Laat, Takashi Iida, Tsuyoshi Kitagawa, Hiroshi Murakami, Takao Kato, Misao Kawara   +7 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

An exploratory case-control study on the impact of IL-1 gene polymorphisms on early implant failure

, 2016
Background: The association between IL-1 gene polymorphisms and peri-implantitis has been well documented. However, data on the association with early implant failure are scarce. Purpose: The objective of this case-control study was to explore the impact
De Paepe, Anne,, Koningsveld, Vincent, Cosyn, Jan,, Paul J. Coucke, Cosyn, JanGE368020001712020000-0001-5042-2875F8D9B8EE-F0ED-11E1-A9DE-61C894A0A6B4, Cosyn, Jan, De Paepe, Anne, Hugo De Bruyn, Jan Cosyn, De Bruyn, Hugo,, Véronique Christiaens, Christiaens, VéroniqueGE36UZGent0000604968768020005940590000-0002-0938-888716A2404E-F0EE-11E1-A9DE-61C894A0A6B4, De Paepe, AnneGE31UZGent8010004612130000-0002-4134-5940F403A000-F0ED-11E1-A9DE-61C894A0A6B4, De Bruyn, HugoGE36UZGent0000705496158010018893350000-0003-0200-9546F73EAFBC-F0ED-11E1-A9DE-61C894A0A6B4, Vincent Koningsveld, Christiaens, Véronique,, Coucke, PaulGE31UZGent0001712314708010016360240000-0001-7119-586XF6730D80-F0ED-11E1-A9DE-61C894A0A6B4, Christiaens, Véronique, Koningsveld, Vincent,, Coucke, Paul, Coucke, Paul J,, De Bruyn, Hugo, De Coster, Peter, Koningsveld, Vincent00006070583291902352098517111D3E-F0EE-11E1-A9DE-61C894A0A6B4, De Coster, Peter,, Peter De Coster, De Coster, PeterGE360019801975078010013777600000-0002-0674-7733F5D3E7D2-F0ED-11E1-A9DE-61C894A0A6B4, Anne De Paepe   +27 more
core   +1 more source