Results 61 to 70 of about 5,946,708 (300)

Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy

Molecular Oncology, EarlyView.
LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir, Elena Haro‐Martínez, Sandra Blasco‐Benito, Chiara Cannatà, José Ángel Palomeque, Anna López‐Plana, Maria Sanz‐Flores, Marc Sabartés, Cristina Fornaguera, Toni Celià‐Terrassa   +9 more
wiley   +1 more source

Late-stage vacuolization as a compaction-dependent prognostic marker for day 4 embryo selection

Reproduction and Fertility
This study aimed to evaluate the prognostic value of late-stage vacuolization in day 4 embryos relative to compaction status. We retrospectively analyzed 9,779 embryos from 2,409 patients undergoing fresh D4 transfers between 2018 and 2024.
Yasong Geng, Aixin Yang, Fangfang Dai, Haoyang Dai, Linlin Tao, Guozhen Li, Chun He, Lingyin Kong, Jing Ma, Bo Zheng, Fang Wang   +10 more
doaj   +1 more source

Prolonged post-thaw culture of embryos does not improve outcomes of frozen human embryo transfer cycles: A prospective randomized study

Asian Pacific Journal of Reproduction, 2019
Objective: To evaluate the impact of prolonged post-thaw embryos culture on pregnancy outcome during frozen embryo transfer cycles. Methods: This prospective cohort study evaluated 324 thaw transfer cycles with 819 embryos from 269 patients at the Center
Minh Tam Le, Van Trung Nguyen, Thanh Tung Nguyen, M Blake Evans, Thai Thanh Thi Nguyen, Tam An Thi Nguyen, Dinh Duong Le, Vu Quoc Huy Nguyen, Ngoc Thanh Cao, Micah J Hill   +9 more
doaj   +1 more source

RNA Sequencing Resolves Cryptic Pathogenic Variants in Mitochondrial Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Mitochondrial diseases are the most common inherited metabolic disorders, characterized by pronounced clinical and genetic heterogeneity that complicates molecular diagnosis. Although DNA‐based sequencing approaches have become standard in genetic testing, up to half of patients remain without a definitive diagnosis.
Zhimei Liu, Xin Duan, Fatemeh Peymani, Jia Wang, Chengjia Bao, Chaolong Xu, Ying Zou, Zixuan Zhang, Yunxi Zhang, Tongyue Li, Martin Pavlov, Junling Wang, Minhan Song, Tianyu Song, Xiaodi Han, Mingxi Sun, Danmin Shen, Ruoyu Duan, Huafang Jiang, Manting Xu, Holger Prokisch, Fang Fang   +21 more
wiley   +1 more source

Experience with Devices implanted fixed-rate pacemakers [PDF]

Thorax, 1973
The fate of 183 implants of Devices TF 2970 fixed-rate pacemakers is analysed. The incidence of clinical complications such as sepsis or skin necrosis, displacement of the electrode, and exit block, and the causes of the 19 deaths are discussed. In 28 of the 183 pacemakers pacing stopped for technical reasons, which are described; the commonest cause ...
H, Siddons, G, Davies
openaire   +2 more sources

Neurochemical Endpoints to Inform Early‐Stage Trials of Spinocerebellar Ataxia 2 and 3 in a Multisite Setting

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Neurochemical levels measured by brain MR spectroscopy (MRS) have been proposed as endpoints for clinical trials in early‐stage spinocerebellar ataxia (SCA) trials. We tested their trial‐readiness by quantifying neurochemicals in three affected brain regions in early‐stage cohorts of SCA2 and SCA3, examining their reproducibility in ...
James M. Joers, Yaqiao Wei, Dinesh K. Deelchand, Adam Berrington, Young Woo Park, Guita Banan, Michal Povazan, Jens T. Rosenberg, André J. W. van der Kouwe, Tetsuo Ashizawa, Khalaf O. Bushara, Chiadi U. Onyike, Sub H. Subramony, Jeremy D. Schmahmann, Brian J. Soher, Peter B. Barker, Thomas H. Mareci, Eva‐Maria Ratai, Lynn E. Eberly, Gülin Öz   +19 more
wiley   +1 more source

Follicular fluid insulin like growth factor-1 (FF IGF-1) is a biochemical marker of embryo quality and implantation rates in in vitro fertilization cycles

Journal of Human Reproductive Sciences, 2013
Context: Insulin-like growth factor-1 (IGF-1) has been reported to play a role in human follicular and embryonic development. However, earlier studies carried out mostly in animal models or in culture mediums supplemented with IGF-1 have been unable to ...
Bindu N Mehta, Natachandra M Chimote, Meena N Chimote, Nishad N Chimote, Nirmalendu M Nath   +4 more
doaj   +1 more source

Integration of Serum Neurofilament Light Chain and Cortical Dysfunction Improves Diagnostic Accuracy in ALS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To determine whether integration of serum neurofilament light chain (NfL) and cortical dysfunction improves diagnostic accuracy in amyotrophic lateral sclerosis (ALS) when applied alongside the Gold Coast criteria (GCC). Methods In this prospective study, 148 participants with suspected ALS were recruited (101 ALS and 47 with ALS ...
Aicee Dawn Calma, Nathan Pavey, Yukiko Tsuji, Amirul Ab Ghapar, Mehdi A.J. van den Bos, Bronwen Orden, Grace Lee, Linda Mekhael, Julie Ryder, Cláudia Santos Silva, David McDonald, Fakhria Kakar, Con Yiannikas, Matthew C. Kiernan, David A. Brown, Parvathi Menon, Steve Vucic   +16 more
wiley   +1 more source

High Dose Rate Oxygen Implantation for Formation of Silicon-on-Insulator Structures

, 1990
We have studied Separation by IMplantation of OXygen (SIMOX) processes using very high dose rates (40–60 μA/cm2). For a dose of 4 × 1017 O+/cm2 at 160 keV, the structure formed by implantation at 50 μA/cm2 is very similar to that associated with lower ...
E. Cortesi, H. Yang, F. Namavar, R. F. Pinizzotto   +3 more
core   +1 more source

Comparison of Day 2 Tubal Embryo Transfer with Day 3 Embryo Transfer into the Uterus of Intracytoplasmic Sperm Injection Derived Human Embryos

Taiwanese Journal of Obstetrics & Gynecology, 2006
Objective: To compare the results of embryo transfer into the uterus (ET) performed on day 3 vs. tubal embryo transfer (TET) on day 2 in couples diagnosed with male factor infertility. Materials and Methods: We collected data from 34 and 110 patients who
Tsai-Fang Lee, Robert Kuo-Kuang Lee, Ming-Huei Lin, Yuh-Ming Hwu, Yu-Fen Chih, Yi-Chun Tsai, Jin-Tsung Su   +6 more
doaj   +1 more source