Results 101 to 110 of about 2,679,990 (305)
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Implementation of Unmanned Aerial Systems Using Close-Range Photogrammetry Techniques (UAS-CRP) for Quantitative (Metric) and Qualitative (Inspection) Tasks Related to Roadway Assets and Infrastructure [Project Summary] [PDF]
5-6944-01One of the main objectives of this implementation project was to validate the TxDOT Unmanned Aircraft Systems (UAS) Flight Operations and User\u2019s Manual (FOM) that was developed as part of the research project 0-6944.
Puppala, Anand J. +2 more
core
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel +12 more
wiley +1 more source
Research Involvement and EngagementBackground Many equity-deserving populations, including those facing structural health inequities, lack support to participate in clinical trials while facing barriers to participation.
Tamara L. Morgan +14 more
doaj +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi +14 more
wiley +1 more source
Annals of General PsychiatryBackground Somatic symptoms are physical symptoms that often arise in response to emotional distress and can significantly impact well-being. Understanding the prevalence and interplay of these symptoms with anxiety and depression is crucial for ...
Dhiya Mahirah +9 more
doaj +1 more source
Personnel time requirements for mobile chest X-ray screening for TB
IJTLD OpenBACKGROUND: Community-based active case finding (ACF) using chest X-ray (CXR) is effective for early TB detection, but implementation is limited by high resource demands.
T.S. Johnson +12 more
doaj +1 more source
Effects of yoga, strength training and advice on back pain: a randomized controlled trial
BMC Musculoskeletal Disorders, 2017 Background Among the working population, non-specific low-back pain and neck pain are one of the most common reasons for sickness absenteeism. The aim was to evaluate the effects of an early intervention of yoga - compared with strength training or ...
Elisabeth Björk Brämberg +4 more
doaj +1 more source