Results 81 to 90 of about 2,679,990 (305)

Using an intersectionality lens to explore barriers and enablers to hepatitis C point-of-care testing: a qualitative study among people who inject drugs and service providers

International Journal for Equity in Health
Background Hepatitis C virus (HCV) infection is a significant global health burden, particularly among people who inject drugs. Rapid point-of-care HCV testing has emerged as a promising approach to improve HCV detection and linkage to care in harm ...
Guillaume Fontaine, Justin Presseau, Julie Bruneau, Cole Etherington, Isabella M. Thomas, Jui-Hsia Cleo Hung, Zack van Allen, Andrea M. Patey, Ayesha Kareem, Sameh Mortazhejri, Stine Bordier Høj, Geneviève Boyer-Legault, Jeremy M. Grimshaw   +12 more
doaj   +1 more source

Designing high-quality implementation research: development, application, feasibility and preliminary evaluation of the implementation science research development (ImpRes) tool and guide

Implementation Science, 2019
Background Designing implementation research can be a complex and daunting task, especially for applied health researchers who have not received specialist training in implementation science.
Louise Hull, Lucy Goulding, Zarnie Khadjesari, Rachel Davis, Andy Healey, Ioannis Bakolis, Nick Sevdalis   +6 more
doaj   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Embedding consumer and community involvement in antenatal healthcare research: A methodological approach and perspectives of culturally and linguistically diverse women in Australia

Research Involvement and Engagement
Background Consumer and Community Involvement (CCI) in healthcare research ensures that the needs of target populations are met through active collaboration between consumers, communities, and researchers. For culturally and linguistically diverse (CALD)
Bonnie R. Brammall, Rebecca L. Madill, Rhonda M. Garad, Bao N. Nguyen, Nitya Nagesh, Cheryce L. Harrison   +5 more
doaj   +1 more source

Designing theoretically-informed implementation interventions. [PDF]

, 2006
Canadian Institutes of Health Research; Ontario Ministry of ...
Improved Clinical Effectiveness through Behavioural Research Group (ICEBeRG)
core  

Synthesis Report: All-island implementation of the Aarhus Convention

, 2022
This report summarises the research carried out for the project ‘Finding Common Ground: Towards All-island implementation of the Aarhus Convention’. This project set out to explore issues with allisland implementation of the Aarhus Convention and what ...
Doran, Peter, Brennan, Ciara, Hough, Alison   +2 more
core  

Accelerating the impact of artificial intelligence in mental healthcare through implementation science.

, 2022
BACKGROUND: The implementation of artificial intelligence (AI) in mental healthcare offers a potential solution to some of the problems associated with the availability, attractiveness, and accessibility of mental healthcare services.
Johansson, Jan, Nilsen, Per, Nilsen, Per,, Frideros, Micael,, Nygren, Jens, Schueller, Stephen, Svedberg, Petra, Schueller, Stephen,, Frideros, Micael, Johansson, Jan,, Nygren, Jens,, Svedberg, Petra,, Nygren, Jens M.,   +12 more
core   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Understanding Perceptions of Hepatitis C and Its Management Among People with Experience of Incarceration in Quebec, Canada: A Qualitative Study Guided by the Common Sense Self-Regulation Model

Viruses
Hepatitis C virus (HCV) disproportionately affects certain sub-populations, including people with experience of incarceration (PWEI). Little is known about how perceptions of HCV and treatment have changed despite simplifications in testing and treatment
Andrea Mambro, Sameh Mortazhejri, David Ortiz-Paredes, Andrea Patey, Guillaume Fontaine, Camille Dussault, Joseph Cox, Jeremy M. Grimshaw, Justin Presseau, Nadine Kronfli   +9 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source