Results 81 to 90 of about 1,647,499 (256)

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Personnel time requirements for mobile chest X-ray screening for TB

IJTLD Open
BACKGROUND: Community-based active case finding (ACF) using chest X-ray (CXR) is effective for early TB detection, but implementation is limited by high resource demands.
T.S. Johnson, J. Kakeeto, D. Isooba, S. Birabwa, J. Magezi, W. Kamya, R. Okura, I. Naluyima, A. Nalutaaya, P.J. Kitonsa, E.A. Kendall, A. Katamba, D.W. Dowdy   +12 more
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Trends in Anemia Prevalence Among Indian Women Using Revised WHO Hemoglobin Cutoffs: Insights From Repeated Cross-Sectional Surveys (1998–2019)

Anemia
Conclusion: This study highlights a decline in anemia prevalence, particularly in severe cases during pregnancy. Anemia reduction efforts must rely on country-specific data, especially on the Hb distribution against the background of ferritin level ...
Anuj Kumar Pandey, Diksha Gautam, Benson Thomas M., Sutapa Bandyopadhyay Neogi   +3 more
doaj   +1 more source

Patient engagement, shared decision-making and equity, diversity and inclusion considerations in research ethics board application forms and templates in Canada: a mixed methods study

BMJ Open
Objectives Equity, diversity and inclusion (EDI), patient engagement and shared decision-making are important considerations throughout clinical trials, including the research ethics review stage. Meaningfully integrating these considerations can enhance
Justin Presseau, Jamie C Brehaut, Kelly Carroll, Cole Etherington, Susan Marlin, Tamara L Morgan, Meena Mosa, Natasha Hudek, Kim Meeking   +8 more
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Building health research infrastructure in Rwanda

The Lancet Global Health, 2014
Rwandan Research and Implementation Writing Group
doaj   +1 more source

Human papillomavirus awareness and vaccination willingness among adults in Madagascar: a cross-sectional study

BMC Women's Health
Disease awareness is key to utilising healthcare services, including vaccinations. Madagascar, with high human papillomavirus (HPV) prevalence (> 36%), marked cervical cancer rates, and low general routine vaccination coverage, faces major challenges in ...
Aaron Remkes, Alexina Zafinimampera, Olivette Totofotsy, Fesia Elveric Ratiaharison, Haingoniavo Garcia Rambeloson, Elly Daus, Myriam Lassmann, Alexandra Schmidt, Fiona Franz, Pia Rausche, Jana Hey, Tiana Randrianarisoa, Tahinamandranto Rasamoelina, Irina Kislaya, Diavolana Andrianarimanana, Jürgen May, Valentina Marchese, Rivo Andry Rakotoarivelo, Daniela Fusco   +18 more
doaj   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source