Results 71 to 80 of about 2,679,990 (305)

Understanding collaborative care implementation in the Department of Veterans Affairs: core functions and implementation challenges

BMC Health Services Research, 2017
Background The collaborative care model is an evidence-based practice for treatment of depression in which designated care managers provide clinical services, often by telephone.
Jessica M. Lipschitz, Justin K. Benzer, Christopher Miller, Siena R. Easley, Jenniffer Leyson, Edward P. Post, James F. Burgess   +6 more
doaj   +1 more source

Identifying strategies for implementing a clinical guideline for cancer-related fatigue: a qualitative study

BMC Health Services Research, 2023
Background Clinical practice guidelines assist health professionals’ (HPs) decisions. Costly to develop, many guidelines are not implemented in clinical settings.
Elizabeth J. Pearson, Linda Denehy, Lara Edbrooke   +2 more
doaj   +1 more source

Enhancing the reporting of implementation research [PDF]

Implementation Science, 2017
In the 10 years since the inception of Implementation Science, we have witnessed a continued rise in the number of submissions received, reflecting the continued global interest in methods to enhance the uptake of research findings into healthcare practice and policy.
Wilson, Paul M, Sales, Anne, Wensing, Michel, Aarons, Gregory A, Flottorp, Signe, Glidewell, Liz, Hutchinson, Alison M., Presseau, Justin, Rogers, Anne, Sevdalis, Nick, Squires, Janet, Straus, Sharon E   +11 more
openaire   +9 more sources

Implementing health research through academic and clinical partnerships : a realistic evaluation of the Collaborations for Leadership in Applied Health Research and Care (CLAHRC) [PDF]

, 2011
Background: The English National Health Service has made a major investment in nine partnerships between higher education institutions and local health services called Collaborations for Leadership in Applied Health Research and Care (CLAHRC).
Baker, R, Martin, G, G. Harvey (6109268), Baker Richard, Graham, Ian D., Burton, C., McCormack Brendan G, Rycroft-Malone, Jo, McCormack, Brendan, Graham, I, Thompson, C, Joyce E Wilkinson, Rycroft-Malone, J, Thompson, Carl, Baker, Richard, I. Graham (7334894), Harvey, G, Staniszewskas, Sophie, Martin, Graham, Burton, Christopher R., Sophie Staniszewska, S. Staniszewska (4327975), Graham, Ian, Graham Martin (3571220), Andrews, G, Andrews Gavin, Graham Martin, Andrews, Gavin, Burton, CR, Martin, Graham P., Wilkinson, J.E., Ariss, S, Harvey Gill, Christopher R Burton, Dopson, Sue, Andrews, G., Steven Ariss, McCormack, B.G., J. E. Wilkinson (7620728), Rycroft-Malone Jo, McCormack, Brendan G., Richard Baker, Martin, G., C. Thompson (7620746), Ariss, Steven, Burton, C.R., McCormack, B., Wilkinson, Joyce, Andrews, Gavin J., Wilkinson Joyce E, J. Rycroft-Malone (6164171), Richard Baker (301808), G. Andrews (7620734), Wilkinson, Joyce E., Harvey, Gill, Rycroft-Malone, J., Wilkinson, J., Brendan G McCormack, Wilkinson, Joyce E, Baker, R., Ian Graham, Martin Graham, Ariss Steven, B. G. McCormack (7620743), Dopson, S., Gill, Harvey, Gavin Andrews, Graham, I., Harvey, G., Thompson Carl, Staniszewska, S., Sue Dopson, Dopson, S, Staniszewska, S, Staniszewska Sophie, Burton Christopher R, McCormack, BG, Thompson, Carl, DPhil, Staniszewska, Sophie, S. Dopson (7620740), Burton, Christopher R, C. R. Burton (7620731), Graham Ian, Gill Harvey, Dopson Sue, Wilkinson, JE, S. Ariss (7620737), Carl Thompson, Thompson, C., Jo Rycroft-Malone, Burton, Christopher, Ariss, S.   +91 more
core   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

iSPARC 2024 Annual Report to the Massachusetts Department of Mental Health

In fiscal year 2024, iSPARC continued to leverage DMH’s investment to rapidly translate research findings into their implementation within best practices for individuals with lived experience, their families, and the providers who serve them across the ...
Implementation Science and Practice Advances Research Center
core   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

External facilitators’ perceptions of internal facilitation skills during implementation of collaborative care for mental health teams: a qualitative analysis informed by the i-PARIHS framework

BMC Health Services Research, 2020
Background Facilitation is a key strategy that may contribute to successful implementation of healthcare innovations. In blended facilitation, external facilitators (EFs) guide and support internal facilitators (IFs) in directing implementation processes.
Samantha L. Connolly, Jennifer L. Sullivan, Mona J. Ritchie, Bo Kim, Christopher J. Miller, Mark S. Bauer   +5 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source