Results 51 to 60 of about 1,647,499 (256)

Patient Perspectives on Implementing a Person-Centered Care System: Experiences From the U.S. Veterans Health Administration's Whole Health System of Care

Patient Experience Journal
Objectives. Replacing the disease-centered, paternalistic approach in healthcare with a person-centered model has become a widely recognized imperative. However, patients' perspectives on and experiences with real-life efforts to implement this approach ...
Ekaterina Anderson, Renda S Wiener, Brianne Molloy-Paolillo, Megan McCullough, Bo Kim, J. Irene Harris, Seppo T. Rinne, Barbara G. Bokhour   +7 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

C-reactive protein as a predictor of mortality in tuberculosis: systematic review and meta-analysis

BMC Infectious Diseases
Background Tuberculosis (TB) remains a leading cause of global mortality, underscoring the need for accessible prognostic tools. C-reactive protein (CRP) is a widely available acute-phase biomarker that may predict outcomes in TB.
Jessica Edelyne, Muhammad Prasetio Wardoyo, Luthfiyah Zanida Putri, Salsabila Hulwani, Assica Permata Amalya Hakiman, R. Muhammad Kevin Baswara, Yogik Onky Silvana Wijaya, Erlina Burhan   +7 more
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Using an intersectionality lens to explore barriers and enablers to hepatitis C point-of-care testing: a qualitative study among people who inject drugs and service providers

International Journal for Equity in Health
Background Hepatitis C virus (HCV) infection is a significant global health burden, particularly among people who inject drugs. Rapid point-of-care HCV testing has emerged as a promising approach to improve HCV detection and linkage to care in harm ...
Guillaume Fontaine, Justin Presseau, Julie Bruneau, Cole Etherington, Isabella M. Thomas, Jui-Hsia Cleo Hung, Zack van Allen, Andrea M. Patey, Ayesha Kareem, Sameh Mortazhejri, Stine Bordier Høj, Geneviève Boyer-Legault, Jeremy M. Grimshaw   +12 more
doaj   +1 more source

Is distance associated with tuberculosis treatment outcomes? A retrospective cohort study in Kampala, Uganda

BMC Infectious Diseases, 2020
Background Challenges accessing nearby health facilities may be a barrier to initiating and completing tuberculosis (TB) treatment. We aimed to evaluate whether distance from residence to health facility chosen for treatment is associated with TB ...
Katherine O. Robsky, Seamus Hughes, Alex Kityamuwesi, Emily A. Kendall, Peter James Kitonsa, David W. Dowdy, Achilles Katamba   +6 more
doaj   +1 more source

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

Embedding consumer and community involvement in antenatal healthcare research: A methodological approach and perspectives of culturally and linguistically diverse women in Australia

Research Involvement and Engagement
Background Consumer and Community Involvement (CCI) in healthcare research ensures that the needs of target populations are met through active collaboration between consumers, communities, and researchers. For culturally and linguistically diverse (CALD)
Bonnie R. Brammall, Rebecca L. Madill, Rhonda M. Garad, Bao N. Nguyen, Nitya Nagesh, Cheryce L. Harrison   +5 more
doaj   +1 more source

External facilitators’ perceptions of internal facilitation skills during implementation of collaborative care for mental health teams: a qualitative analysis informed by the i-PARIHS framework

BMC Health Services Research, 2020
Background Facilitation is a key strategy that may contribute to successful implementation of healthcare innovations. In blended facilitation, external facilitators (EFs) guide and support internal facilitators (IFs) in directing implementation processes.
Samantha L. Connolly, Jennifer L. Sullivan, Mona J. Ritchie, Bo Kim, Christopher J. Miller, Mark S. Bauer   +5 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source