Results 41 to 50 of about 1,647,499 (256)

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Assessing the sustainability of compliance with surgical site infection prophylaxis after discontinuation of mandatory active reporting: study protocol

Implementation Science Communications, 2022
Background Surgical site infections are common. Risk can be reduced substantially with appropriate preoperative antimicrobial administration. In 2005, the VA implemented the Surgical Care Improvement Project (SCIP) in the setting of high rates of non ...
Westyn Branch-Elliman, A. Rani Elwy, Rebecca L. Lamkin, Marlena Shin, Ryann L. Engle, Kathryn Colborn, Jessica Rove, Jacquelyn Pendergast, Kierstin Hederstedt, Mary Hawn, Hillary J. Mull   +10 more
doaj   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Predicting suicide death among veterans after psychiatric hospitalization using transformer based models with social determinants and NLP

Scientific Reports
Predictions of suicide death of patients discharged from psychiatric hospitals (PDPH) can guide intervention efforts including intensive post-discharge case management programs, designed to reduce suicide risk among high-risk patients. This study aims to
Zhichao Yang, Avijit Mitra, Wen Hu, Dan Berlowitz, Hong Yu   +4 more
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Understanding collaborative care implementation in the Department of Veterans Affairs: core functions and implementation challenges

BMC Health Services Research, 2017
Background The collaborative care model is an evidence-based practice for treatment of depression in which designated care managers provide clinical services, often by telephone.
Jessica M. Lipschitz, Justin K. Benzer, Christopher Miller, Siena R. Easley, Jenniffer Leyson, Edward P. Post, James F. Burgess   +6 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Implementing findings of research revisited [PDF]

Family Practice, 1999
In 1994 Haines and Jones described and reviewed the reasons for “unacceptable delays in the implementation of many findings of research”. 1 They concluded, from a wide-ranging discussion, that any single approach to enhancing the implementation of research findings was unlikely to be effective, and that a shift in attitude towards a more evaluative ...
T, Lipman, R, Jones
openaire   +2 more sources