Results 51 to 60 of about 6,676,759 (283)

Factors Affecting Implementation of the California Childhood Obesity Research Demonstration (CA-CORD) Project, 2013. [PDF]

, 2016
IntroductionEcological approaches to health behavior change require effective engagement from and coordination of activities among diverse community stakeholders. We identified facilitators of and barriers to implementation experienced by project leaders
Ayala, Guadalupe X, Binggeli-Vallarta, Amy, Brunner, Julian, Cervantes, Griselda, Chuang, Emmeline, Finlayson, Tracy L, Hoyt, Helina, Ibarra, Leticia, McKenzie, Thomas L, Moody, Jamie   +9 more
core   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Is distance associated with tuberculosis treatment outcomes? A retrospective cohort study in Kampala, Uganda

BMC Infectious Diseases, 2020
Background Challenges accessing nearby health facilities may be a barrier to initiating and completing tuberculosis (TB) treatment. We aimed to evaluate whether distance from residence to health facility chosen for treatment is associated with TB ...
Katherine O. Robsky, Seamus Hughes, Alex Kityamuwesi, Emily A. Kendall, Peter James Kitonsa, David W. Dowdy, Achilles Katamba   +6 more
doaj   +1 more source

What Does it Take to Make Discovery a Success?: A Survey of Discovery Tool Adoption, Instruction, and Evaluation Among Academic Libraries [PDF]

, 2017
Discovery tools have been widely adopted by academic libraries, yet little information exists that connects common practices regarding discovery tool implementation, maintenance, assessment, and staffing with conventions for research and instruction. The
Allison, Megan, Crist, Emily A, Nichols, Aaron, Sherriff, Graham   +3 more
core   +2 more sources

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Predicting suicide death among veterans after psychiatric hospitalization using transformer based models with social determinants and NLP

Scientific Reports
Predictions of suicide death of patients discharged from psychiatric hospitals (PDPH) can guide intervention efforts including intensive post-discharge case management programs, designed to reduce suicide risk among high-risk patients. This study aims to
Zhichao Yang, Avijit Mitra, Wen Hu, Dan Berlowitz, Hong Yu   +4 more
doaj   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Implementation research: Issues and prospects [PDF]

Addictive Behaviors, 2011
The concern that addiction treatment be grounded in science has been recognized and enthusiastically endorsed in both the clinical and research communities. With recognition of the gap between knowledge development and application, there has been a recent emphasis on developing strategies for more effective application, i.e., for the incorporation of ...
Patrick M, Flynn, Barry S, Brown
openaire   +2 more sources

Evaluation of the implementation of curriculum materials for civics in the Netherlands [PDF]

, 1995
Discusses a study evaluating the implementation of curriculum materials for civics in the Netherlands. Pedagogical principles aimed at increasing students' social commitment; Central research question; Exploration of broad context for implementation ...
Akker, Jan van den, Kuiper, Wilmad
core   +2 more sources