Results 71 to 80 of about 665,454 (302)
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
IMPLEMENTATION STRATEGY ON BEEF CATTLE DEVELOPMENT THROUGH THE LIVESTOCK ASSISTANCE PROGRAM IN GORONTALO DISTRICT, INDONESIA [PDF]
Russian Journal of Agricultural and Socio-Economic SciencesThis research aims to analyze alternative strategic priorities in the beef cattle assistance program that can be implemented in Gorontalo Regency. The research was carried out in Gorontalo Regency.
Kadir L.P., Pateda S.Y., Sahara L.O.
doaj
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
LHB Hydroscience JournalLe Service Prévision des Crues Vilaine et Côtiers Bretons (SPC VCB) est responsable de la vigilance crues sur les cours d’eau à enjeux de la région Bretagne depuis 2005. Depuis presque 20 ans, les attentes des gestionnaires de crise comme du grand public
Robin Treilles +7 more
doaj +1 more source
A Model for Identifying and Analyzing of Strategy Implementation Barriers [PDF]
مطالعات مدیریت راهبردی, 2016 This research designs a model for Identifying and Analyzing of Strategy Implementation Barriers in Saman Bank. At first, the theoretical principals and concepts are reviewed and then measuring indicators of each index and dimension are derived by the ...
Mohammad Ali Babayi Zekilaki +3 more
doaj
Molecular Oncology, EarlyView.To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley +1 more source
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
THE IMPACT OF STRATEGY ON ICT PROJECTS
Journal of ICT, 2004 Strategic planning processes are oriented towards the selection of objectives and product/market choices by senior management. From this viewpoint strategic planning provides a mechanism for setting and reviewing objectives, focusing on choices of long ...
G. Udechukwu Ojiako +2 more
doaj
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source