Results 181 to 190 of about 212,820 (287)

Sustained increase in measles cases prompts the Americas to strengthen surveillance, rapid response and vaccination efforts. [PDF]

Rev Panam Salud Publica
Pan American Health Organization.
europepmc   +1 more source

Single‐Mitochondrion ATP Profiling Directs Discovery of Targetable OXPHOS Dependency in Cancers

Advanced Science, EarlyView.
MitoATP‐nFCM integrates nano‐flow cytometry with fluorogenic probes (ATP/membrane potential) and antibodies to quantify mitochondrial metabolites and protein expression at single‐organelle resolution, exposing oxidative phosphorylation (OXPHOS)‐driven metabolic rewiring in cancers.
Xu Xiao, Cheng Lu, Hao Chen, Jing Zhou, Yunyun Hu, Haonan Di, Guoqiang Su, Xiaomei Yan   +7 more
wiley   +1 more source

Sortilin exhibits tumor suppressor-like activity by limiting EGFR transduction function. [PDF]

Oncogene
Lapeyronnie E, Granet C, Tricard J, Gallet F, Yassine M, Daverat H, Rovini A, Chermat A, Jauberteau MO, Bertin F, Melloni B, Vincent F, Naves T, Lalloué F.   +13 more
europepmc   +1 more source

Endocytic Control of Cell‐Autonomous and Non‐Cell‐Autonomous Functions of p53

Advanced Science, EarlyView.
NUMB Ex3‐containing isoforms localize to the plasma membrane, where they recruit p53 through SNX9 and direct it to multivesicular bodies and exosomes. Exported p53 is taken up by neighboring cells and activates nuclear programs, revealing an intercellular, exosome‐based pathway that might help establish a tumor‐suppressive microenvironment.
Roberta Cacciatore, Andrea Basile, Stefano Freddi, Irene Schiano Lomoriello, Carlo Ribelle Zucca, Giuseppe Ciossani, Luigi Scietti, Alessandro Cuomo, Simona Ronzoni, Simone Pelicci, Mario Faretta, Elena Zaccheroni, Giuliana Pelicci, Vittoria Matafora, Angela Bachi, Rosalind Helen Gunby, Salvatore Pece, Sara Sigismund, Letizia Lanzetti, Ivan Nicola Colaluca, Pier Paolo Di Fiore   +20 more
wiley   +1 more source

Assessing early detection ability through spatial arrangements in environmental surveillance for poliovirus: A simulation-based study. [PDF]

PLoS One
Asakura TR, O'Reilly KM.
europepmc   +1 more source

Proposal for a Council Directive determining the scope of Article 4(1)(d) of Directive 77/388/EEC as regards exemption from value added tax on the final importation of certain goods. SEC (90) 2249 final, 29 November 1990 [PDF]

, 1990

core  

Engineered GM1 Intersects Between Mitochondrial and Synaptic Pathways to Ameliorate ALS Pathology

Advanced Science, EarlyView.
Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease driven by genetic and molecular disruptions affecting energy balance, protein homeostasis, and stress responses in nerve cells. Studies using human and rodent models identified convergent defects in mitochondria and synaptic function.
Federica Pilotto, Tristan Dellazizzo Toth, Silvano Bond, Alexander Schmitz, Rim Diab, Sara Y. Ngo Tenlep, Brian Mooney, Silvia Erni, Martina Schobesberger, Olivier Scheidegger, Camille Peitsch, Smita Saxena   +11 more
wiley   +1 more source

When Few Mosquitoes Are Enough: Dengue outbreaks in non-endemic areas. [PDF]

One Health
Pisaneschi G, Manfredi P, Landi A, Stollenwerk N, Aguiar M.   +4 more
europepmc   +1 more source

Metabolic Regulation of Dimethylsulfoniopropionate Cleavage and Dimethyl Sulfide Production in Halomonas sp. D47

Advanced Science, EarlyView.
Dimethylsulfoniopropionate (DMSP) is a major marine organosulfur compound central to climate‐relevant dimethyl sulfide (DMS) production. In Halomonas sp. D47, DMSP catabolism is revealed to be coordinated by two transcriptional regulators, AcuR and AcuZ, which control gene expression by sensing DMSP and its metabolites.
Li‐Yuan Zheng, Wen‐Xin Jiang, Xiao‐Meng Sun, Li Liu, Zhao‐Jie Teng, Hou‐Qi Wang, Wen‐Jing Zhu, Chang Ge, Qi‐Long Qin, Ning‐Hua Liu, Hai‐Yan Cao, Hui‐Hui Fu, Chun‐Yang Li, Jonathan D. Todd, Xiu‐Lan Chen, Yu‐Zhong Zhang, Peng Wang   +16 more
wiley   +1 more source

Reconstructing the early spatial spread of pandemic respiratory viruses in the United States. [PDF]

Proc Natl Acad Sci U S A
Zhang R, Deng R, Liu S, Yao Q, Shaman J, Grenfell BT, Viboud C, Pei S.   +7 more
europepmc   +1 more source