Results 191 to 200 of about 21,607 (213)

Towards a universal cross-linking mass spectrometry approach for protein structure analysis with homo-bi-functional photo-activatable cross-linkers. [PDF]

Commun Biol
Ser Z, Ong AGM, Wang SM, Sobota RM.
europepmc   +1 more source

Cloning of two novel human importin-α subunits and analysis of the expression pattern of the importin-α protein family [PDF]

FEBS Letters, 1997
The import of many proteins into the nucleus is mediated by the importin-α/β heterodimer. While only one importin-β gene has been found, several forms of importin-α have been described.
Achim Leutz, Stéphane Ansieau, Enno Hartmann   +2 more
exaly   +2 more sources

Nuclear import of the thyroid hormone receptor α1 is mediated by importin 7, importin β1, and adaptor importin α1

Molecular and Cellular Endocrinology, 2016
The thyroid hormone receptor a1 (TRa1) is a nuclear receptor for thyroid hormone that shuttles rapidly between the nucleus and cytoplasm. Our prior studies showed that nuclear import of TRa1 is directed by two nuclear localization signals, one in the N ...
Lizabeth A Allison, Vincent R Roggero
exaly   +2 more sources

Some of the next articles are maybe not open access.

Related searches:

Discovery of Highly Potent Daphnane Diterpenoids Uncovers Importin-β1 as a Druggable Vulnerability in Castration-Resistant Prostate Cancer.

Journal of the American Chemical Society, 2022
Importins are overexpressed in many cancers and mediate the abnormal nuclear transport of oncogenic factors. The druggable potential of importins still remains unclear, largely because of the lack of potent inhibitors.
Jia-Luo Huang, Xue-Long Yan, Wei Li, Run-Zhu Fan, Shen Li, Jiang-liang Chen, Zhe Zhang, Jun Sang, Lu Gan, Gui-Hua Tang, Hongwu Chen, Jun-Jian Wang, Sheng Yin   +12 more
semanticscholar   +1 more source

The broad spectrum antiviral ivermectin targets the host nuclear transport importin α/β1 heterodimer.

Antiviral Research, 2020
Infection by RNA viruses such as human immunodeficiency virus (HIV)-1, influenza, and dengue virus (DENV) represent a major burden for human health worldwide.
Sundy N. Y. Yang, Sarah C Atkinson, Chunxiao Wang, Alexander Lee, M. Bogoyevitch, N. A. Borg, D. Jans   +6 more
semanticscholar   +1 more source

The sequence [EKRKI(E/R)(K/L/R/S/T)] is a nuclear localization signal for importin 7 binding (NLS7).

Biochimica et Biophysica Acta - General Subjects, 2021
BACKGROUND Nuclear translocation of large proteins is mediated through specific protein carriers, collectively named karyopherins (importins, exportins and adaptor proteins).
Athanasios Panagiotopoulos, Chara Polioudaki, Sotirios G. Ntallis, D. Dellis, G. Notas, C. Panagiotidis, P. Theodoropoulos, E. Castanas, M. Kampa   +8 more
semanticscholar   +1 more source

Functional characterization of importin α8 as a classical nuclear localization signal receptor [PDF]

Biochimica Et Biophysica Acta - Molecular Cell Research, 2015
Importin α8 has recently been identified as an importin α family member based on its primary structure and binding ability to importin β1 and to several karyophilic proteins.
Masahiro Oka, Yoichi Miyamoto, Chikashi Obuse   +2 more
exaly   +2 more sources

Genetic loss of importin α4 causes abnormal sperm morphology and impacts on male fertility in mouse

The FASEB Journal, 2020
Importin α proteins play a central role in the transport of cargo from the cytoplasm to the nucleus. In this study, we observed that male knock‐out mice for importin α4, which is encoded by the Kpna4 gene (Kpna4−/−), were subfertile and yielded smaller ...
Y. Miyamoto, Mitsuho Sasaki, Haruhiko Miyata, Yoko Monobe, Masahiro Nagai, M. Otani, Penny A. F. Whiley, A. Morohoshi, Shinya Oki, J. Matsuda, K. Akagi, J. Adachi, M. Okabe, M. Ikawa, Y. Yoneda, K. L. Loveland, M. Oka   +16 more
semanticscholar   +1 more source

Human importin α3 and its N-terminal truncated form, without the importin-β-binding domain, are oligomeric species with a low conformational stability in solution.

Biochimica et Biophysica Acta - General Subjects, 2020
BACKGROUND Eukaryotic cells have a continuous transit of macromolecules between the cytoplasm and the nucleus. Several carrier proteins are involved in this transport. One of them is importin α, which must form a complex with importin β to accomplish its
Clara Díaz-García, Felipe Hornos, A. Giudici, A. Cámara-Artigas, J. R. Luque-Ortega, A. Arbe, B. Rizzuti, Carlos Alfonso, J. Forwood, J. Iovanna, Javier Gómez, M. Prieto, A. Coutinho, J. Neira   +13 more
semanticscholar   +1 more source

Identification of a nuclear localization signal and importin beta members mediating NUAK1 nuclear import inhibited by oxidative stress

Journal of Cellular Biochemistry, 2019
NUAK1 is a serine/threonine kinase member of the AMPK‐α family. NUAK1 regulates several processes in tumorigenesis; however, its regulation and molecular targets are still poorly understood.
M. Palma, E. Riffo, Tamaki Suganuma, M. Washburn, J. Workman, R. Pincheira, Ariel F. Castro   +6 more
semanticscholar   +1 more source