Results 171 to 180 of about 16,651 (218)

Importin α transports CaMKIV to the nucleus without utilizing importin β

Importin α transports CaMKIV to the nucleus without utilizing importin β
openaire  

Nuclear import of the thyroid hormone receptor α1 is mediated by importin 7, importin β1, and adaptor importin α1

Molecular and Cellular Endocrinology, 2016
The thyroid hormone receptor α1 (TRα1) is a nuclear receptor for thyroid hormone that shuttles rapidly between the nucleus and cytoplasm. Our prior studies showed that nuclear import of TRα1 is directed by two nuclear localization signals, one in the N-terminal A/B domain and the other in the hinge domain.
Vincent R Roggero, Lizabeth A Allison
exaly   +5 more sources

Cloning of two novel human importin-α subunits and analysis of the expression pattern of the importin-α protein family

FEBS Letters, 1997
The import of many proteins into the nucleus is mediated by the importin-α/β heterodimer. While only one importin-β gene has been found, several forms of importin-α have been described.
M Kohler, Stéphane Ansieau, Achim Leutz   +2 more
exaly   +2 more sources

Nuclear import factors importin α and importin β undergo mutually induced conformational changes upon association [PDF]

FEBS Letters, 2000
A heterodimer of importin α and importin β accomplishes the nuclear import of proteins carrying classical nuclear localization signals (NLS). The interaction between the two import factors is mediated by the IBB domain of importin α and involves an ...
Gino Cingolani, Hilal A Lashuel, Larry Gerace   +2 more
exaly   +3 more sources

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The importins of pain

Science, 2020
A nuclear protein importer modulates gene expression to control the persistence of neuropathic ...
Muhammad Saad, Yousuf, Theodore J, Price
openaire   +2 more sources

Importin alpha can migrate into the nucleus in an importin beta- and Ran-independent manner [PDF]

EMBO Journal, 2002
A classical nuclear localization signal (NLS)-containing protein is transported into the nucleus via the formation of a NLS-substrate/importin alpha/beta complex. In this study, we found that importin alpha migrated into the nucleus without the addition of importin beta, Ran or any other soluble factors in an in vitro transport assay. A mutant importin
Yoichi Miyamoto, Michelle T Harreman, Alec E Hodel   +2 more
exaly   +3 more sources

Functional characterization of importin α8 as a classical nuclear localization signal receptor

Biochimica Et Biophysica Acta - Molecular Cell Research, 2015
Importin α8 has recently been identified as an importin α family member based on its primary structure and binding ability to importin β1 and to several karyophilic proteins.
Chikashi Obuse, Yoichi Miyamoto, Masahiro Oka   +2 more
exaly   +2 more sources

Importin α Partitioning to the Plasma Membrane Regulates Intracellular Scaling [PDF]

Cell, 2019
Early embryogenesis is accompanied by reductive cell divisions requiring that subcellular structures adapt to a range of cell sizes. The interphase nucleus and mitotic spindle scale with cell size through both physical and biochemical mechanisms, but ...
Christopher W Brownlee, Rebecca Heald
exaly   +2 more sources

The importin β/importin 7 heterodimer is a functional nuclear import receptor for histone H1 [PDF]

EMBO Journal, 1999
Import of proteins into the nucleus proceeds through nuclear pore complexes and is largely mediated by nuclear transport receptors of the importin beta family that use direct RanGTP-binding to regulate the interaction with their cargoes. We investigated nuclear import of the linker histone H1 and found that two receptors, importin beta (Impbeta) and ...
Werner Albig, Ulrike Kutay, F R Bischoff   +2 more
exaly   +4 more sources