Results 101 to 110 of about 71,909 (259)

Reprogramming Antitumor Immunity: NK Cell Strategies to Navigate the Immunosuppressive Tumor Microenvironment

Advanced Science, EarlyView.
ABSTRACT Tumor immune escape is a major barrier to durable cancer immunotherapy, as advanced malignancies create a tumor microenvironment (TME) that preferentially exhausts and disables T cell responses. While most approved cell therapies are T cell‐based, this limitation motivates the exploration of an alternative effector cell platform.
Tereza Kochs, Pranay Nath, Alice Chen, Rizwan Romee, Andreia Maia   +4 more
wiley   +1 more source

Paternal Caffeine Exposure Programs Offspring Stress Vulnerability via Sperm Dlk1‐Dio3 Imprinting‐Directed Remodeling of a Novel Neural Circuit

Advanced Science, EarlyView.
The study elucidates that paternal preconception stress can drive offspring hyperresponsivity of the stress system via hypomethylation of a specific DNA region in sperm. This key link is confirmed in a cohort of prospective fathers: the epigenetic alteration is associated with elevated stress hormone levels.
Mengxi Lu, Gaole Dai, Sen Zhu, Shuai Zhang, Tingting Wang, Yuan Meng, Fang Yang, Xiaoyi Han, Hui Wang, Hao Kou, Dan Xu   +10 more
wiley   +1 more source

Scalable Engineering of Bio‐Manufactured Extracellular Vesicles for Selective Delivery in Ovarian Cancer Patient‐Derived Models

Advanced Science, EarlyView.
Engineered extracellular vesicles displaying Ephrin‐B2 selectively target Ephrin‐B4–expressing ovarian cancer cells, enabling precise delivery in patient‐derived models. This scalable bio‐manufacturing platform reveals a versatile strategy to exploit Ephrin signaling for highly specific therapeutic payload delivery and motivates exploration of tailored
Nihar Godbole, Andrew Lai, Alexander Quinn, Marianne Gillard, Dominic Guanzon, Katherin Scholz‐Romero, Alexis Salas‐Burgos, Bastián Lillo Dapremont, Rohan Lourie, Naven Chetty, Richard Lobb, Kate Beecher, Amy E. McCart Reed, Kaltin Ferguson, Biao Sun, Yaowu He, John D. Hooper, Carlos Salomon   +17 more
wiley   +1 more source

Helical Electron Beam Micro‐Bunching by High‐Order Modes in a Micro‐Plasma Waveguide

Advanced Science, EarlyView.
ABSTRACT Electron acceleration by a high‐power Laguerre‐Gaussian pulse in a micro‐plasma waveguide is investigated. When the incident laser travels in the waveguide, electrons on the wall are extracted into the vacuum core and accelerated by the longitudinal field of the waveguide mode.
Xingju Guo, Longqing Yi
wiley   +1 more source

Metasurface‐Enabled Active‐Like Passive Radar

Advanced Science, EarlyView.
A programmable space‐time‐coding metasurface embeds distinct spatiotemporal tags into ambient wireless signals, allowing passive radar to operate in an active‐like manner. By enabling code‐correlated reconstruction under interference, the approach supports robust real‐time UAV tracking in complex environments and points to intelligent, low‐power ...
Mingyi Li, Jiawen Xu, Hanting Zhao, Xu Zhao, Yanjin Chen, Tie Jun Cui, Vincenzo Galdi, Lianlin Li   +7 more
wiley   +1 more source

Simultaneous chiral separation using a combinatorial molecular imprinting phase

, 2000
Molecular imprinting chiral stationary phase against Cbz-L-Serine (Cbz-L-Ser) and Cbz-L-Alaine (Cbz-L-Ala) were prepared utilizing acrylamide + 2-vinylpyridine as combined basic functional monomers.
Wang, JF, Zhu, DQ, Zhou, LM, Wang, QH, Liu, XL   +4 more
core  

Bias‐Engineered Synthetic Antiferromagnets Hosting Sub‐20 nm Zero‐Field Skyrmions at Room Temperature

Advanced Science, EarlyView.
A fully compensated synthetic antiferromagnet (SAF) multilayer exhibits a uniform state at zero field, without skyrmions. We use a SAF bias system to provide RKKY‐mediated exchange bias to the SAF multilayer, promoting zero‐field skyrmion stabilization and polarity control.
Emily Darwin, Riccardo Tomasello, Reshma Peremadathil Pradeep, Mario Carpentieri, Giovanni Finocchio, Hans J. Hug   +5 more
wiley   +1 more source

New cocktail functional monomers in making molecule imprinting polymer with high chiral selectivity

, 1999
in order td produce molecule imprinting polymer (MIP) with high chiral selectivity against N-c-protected amino acid, new cocktail functional monomers acrylamide (AM) + 2-vinylpyridine (2-VP) and AM + methacrylic acid (MAA) were investigated.
Wang, JF, Zhu, DQ, Meng, ZH, Zhou, LM, Wang, QH   +4 more
core  

A General Enzymatic Strategy for Site‐Specific Incorporation of Modified Genetic Building Blocks Into DNA

Advanced Science, EarlyView.
Eco‐friendly enzymatic synthesis of high‐fidelity, site‐specifically modified DNA using 3′‐blocked nucleotides for full synthetic control and next‐generation sequencing compatibility. ABSTRACT Methods for site‐specific incorporation of modified DNA building blocks remain limited.
Raveena Raveena, Bhavana Ramadas, Sidney Becker   +2 more
wiley   +1 more source

Imprinting in mammals

, 2011
1 ABSTRACT Genomic imprinting is a form of epigenetic regulation that results in gene expression from a single allele in a parent-of-origin manner. It is a form of monoallelic gene expression, another forms of monoallelic expression are X chromosome ...
Hejkrlíková, Zuzana
core