Trichostatin A rescues the disrupted imprinting induced by somatic cell nuclear transfer in pigs. [PDF]
PLoS ONE, 2015 Imprinting disorders induced by somatic cell nuclear transfer (SCNT) usually lead to the abnormalities of cloned animals and low cloning efficiency.
Yanjun Huan +5 more
doaj +1 more source
Very small deletions within the NESP55 gene in pseudohypoparathyroidism type 1b
, 2014 Pseudohypoparathyroidism (PHP) is caused by reduced expression of genes within the GNAS cluster, resulting in parathormone resistance. The cluster contains multiple imprinted transcripts, including the stimulatory G protein α subunit (Gs-α) and NESP55 ...
Mackay, Deborah J.G. +5 more
core +1 more source
Effects of reprogramming on genomic imprinting and the application of pluripotent stem cells
Stem Cell Research, 2019 Pluripotent stem cells are considered to be the ideal candidates for cell-based therapies in humans. In this regard, both nuclear transfer embryonic stem (ntES) cells and induced pluripotent stem (iPS) cells are particularly advantageous because patient ...
Xiajun Li +3 more
doaj +1 more source
Alteration of Genomic Imprinting after Assisted Reproductive Technologies and Long-Term Health
Life, 2021 Assisted reproductive technologies (ART) are the treatment of choice for some infertile couples and even though these procedures are generally considered safe, children conceived by ART have shown higher reported risks of some perinatal and postnatal ...
Eguzkine Ochoa
doaj +1 more source
Olfaction scaffolds the developing human from neonate to adolescent and beyond [PDF]
, 2020 The impact of the olfactory sense is regularly apparent across development. The foetus is bathed in amniotic fluid that conveys the mother’s chemical ecology.
Durand, Karine +4 more
core +3 more sources
A Molecular Study of 136 Patients with an Imprinting Defect [PDF]
, 2003 Prader-Willi syndrome (PWS) and Angelman syndrome (AS) are neurogenetic disorders that are caused by the loss of function of imprinted genes in 15q11-q13. In a small group of patients, the disease is due to aberrant imprinting and gene silencing.
Buiting, Karin +5 more
core +1 more source
The impact of assisted reproductive technologies on genomic imprinting and imprinting disorders [PDF]
Current Opinion in Obstetrics & Gynecology, 2014 Genomic imprinting refers to preferential allele-specific gene expression. DNA methylation-based molecular mechanisms regulate establishment and maintenance of parental imprints during early embryo development and gametogenesis. Because of the coincident timing, a potential association between assisted reproductive technology (ART) procedures and ...
Asli, Uyar, Emre, Seli
openaire +2 more sources
CRISPR/Cas9 Epigenome Editing Potential for Rare Imprinting Diseases: A Review
Cells, 2020 Imprinting diseases (IDs) are rare congenital disorders caused by aberrant dosages of imprinted genes. Rare IDs are comprised by a group of several distinct disorders that share a great deal of homology in terms of genetic etiologies and symptoms ...
Linn Amanda Syding +3 more
doaj +1 more source
The consequences of nuclear transfer for mammalian foetal development and offspring survival : a mitochondrial DNA perspective [PDF]
, 2004 Review of the articleThe introduction of nuclear transfer (NT) and other technologies that involve embryo reconstruction require us to reinvestigate patterns of mitochondrial DNA (mtDNA) transmission, transcription and replication.
Anderson +80 more
core +1 more source
Environmental Exposures during Puberty: Window of Breast Cancer Risk and Epigenetic Damage. [PDF]
, 2020 During puberty, a woman's breasts are vulnerable to environmental damage ("window of vulnerability"). Early exposure to environmental carcinogens, endocrine disruptors, and unhealthy foods (refined sugar, processed fats, food additives) are hypothesized ...
Aljaber, Dana +19 more
core +1 more source