Results 51 to 60 of about 8,912,801 (239)

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

IDE-SVM algorithm and it's usage in physical layer security method for IoT

Xibei Gongye Daxue Xuebao
To address the problem that there is no standard for the parameter selection of support vector machine (SVM) algorithm, a parameter optimization selection method based on the integrated improved differential evolution (IDE) algorithm is proposed, which ...
WANG Qiang, ZHU Chenming, PAN Su, QIN Yuxi   +3 more
doaj   +1 more source

Multi-stage method to identify structural damage using multiple damage location assurance criterion and an improved differential evolution algorithm

International Journal of Computational Intelligence Systems, 2017
For the damage identification technique of civil structures, the reduction of the computational cost for methods based on the optimization algorithms is the most crucial step.
Chunli Wu, Hanbing Liu, Xuxi Qin, Guojin Tan, Zhengwei Gu   +4 more
doaj   +1 more source

Multi-objective Optimization Configuration of Capacitor Blocking Devices Based on Field-Circuit Coupled Model and Improved Differential Evolution Algorithm

Zhongguo dianli, 2020
Based on the operating characteristics of the DC blocking devices, this paper analyzes the influence of the DC blocking devices on the DC current near the neutral point of the transformers, and proposes a multi-objective optimization configuration method
Hongwei LIU
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Global Path Planning for Articulated Steering Tractor Based on Multi-Objective Hybrid Algorithm

Sensors
With the development of smart agriculture, autopilot technology is being used more and more widely in agriculture. Because most of the current global path planning only considers the shortest path, it is difficult to meet the articulated steering tractor
Ning Xu, Zhihe Li, Na Guo, Te Wang, Aijuan Li, Yumin Song   +5 more
doaj   +1 more source

An Improved Differential Evolution Algorithm for Maritime Collision Avoidance Route Planning

Abstract and Applied Analysis, 2014
High accuracy navigation and surveillance systems are pivotal to ensure efficient ship route planning and marine safety. Based on existing ship navigation and maritime collision prevention rules, an improved approach for collision avoidance route ...
Yu-xin Zhao, Wang Li, Shaojun Feng, Washington Y. Ochieng, Wolfgang Schuster   +4 more
doaj   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Hybrid differential evolution - Scatter search algorithm for permutative optimization [PDF]

, 2016
This chapter deals with modified version of DE algorithm, enriched by scatter search to show its improved performance.
Zelinka, Ivan, Davendra, Donald David, Onwubolu, Godfrey   +2 more
core   +1 more source