Results 61 to 70 of about 36,659 (292)
, 2023 To reduce logistics scheduling costs and energy consumption, this paper studies the slab allocation and hot-rolling scheduling integrated optimization problem that arises in practical iron and steel enterprises. In this problem, slabs are first allocated
Ying Meng +3 more
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Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
IADE: An Improved Differential Evolution Algorithm to Preserve Sustainability in a 6G Network
, 2021 IADE: An Improved Differential Evolution Algorithm to Preserve Sustainability in a 6G ...
Z Zhou (7793243) +3 more
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MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Vehicle Routing Problem with Time Windows Based on Improved Differential Evolution Algorithm
, 2009 The paper redefines differential evolution algorithm's mutation and crossover operations for dealing with discrete problems effectively, and it also introduces a variation mechanism to avoid individual stagnation. Then the improved differential evolution
Jian-Wen Wu, Chuan He, Yuan-Biao Zhang
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Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
, 2020 In this article, an effective metaheuristic algorithm named multi-trial vector-based differential evolution (MTDE) is proposed. The MTDE is distinguished by introducing an adaptive movement step designed based on a new multi-trial vector approach named ...
Mirjalili, S +3 more
core +1 more source
Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis
Molecular Oncology, EarlyView.This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht +3 more
wiley +1 more source
Algoritmos evolutivos adaptativos para problemas de programação de pessoal [PDF]
, 2012 Tese (doutorado) - Universidade Federal de Santa Catarina, Centro Tecnológico, Programa de Pós-Graduação em Engenharia de ProduçãoA crescente concorrência mundial tem estimulado empresas a tornar seus produtos mais competitivos e serviços mais eficazes ...
Rosário, Raimundo Ronilson Leal do
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, 2013 The application of two techniques for the reconstruction of shape reconstruction of a metallic cylinder from scattered field measurements is studied in this paper.
Sun, Chi-Hsien; Chiu, Chien-Ching; Ho, Min-Hui; Li, Ching-Lieh +1 more
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